Evaluation of a new quantitative point-of-care test platform for urine-based detection of bladder cancer

Urologic Oncology
Rene RitterT Todenhöfer

Abstract

Several commercial point-of-care (POC) tests are available for urine-based detection of bladder cancer (BC). However, these tests are restricted to dichotomized results (positive or negative), which limits their diagnostic value. Quantitative protein-based tests offer improved risk stratification but require complex methods restricted to specialized centers. Recently, the first quantitative POC system based on the detection of cytokeratin fragments became available. The aim of the study was to evaluate the diagnostic accuracy of this quantitative POC test. A total of 198 patients having symptoms suspicious for BC were included. All patients received urethrocystoscopy and upper-tract imaging. Urine samples were analyzed by the urine BC antigen (UBC) rapid POC system and evaluated both visually and quantitatively using the concile Omega 100 POC reader. For visual evaluation, different thresholds of band intensity for considering a test positive were applied. Moreover, the UBC enzyme-linked immunosorbent assay (ELISA), urine cytology, and the nuclear matrix protein 22 BladderChek were performed. Sensitivities and specifities were calculated by contingency analyses. Optimal cutoffs of quantitative tests were determined by receiver ...Continue Reading

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Citations

Nov 29, 2015·The Urologic Clinics of North America·Aurélie MbeutchaShahrokh F Shariat
May 5, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Thorsten H EckeHolger Gerullis
Feb 23, 2018·The Analyst·Puja Sandbhor Gaikwad, Rinti Banerjee
May 1, 2018·Expert Review of Molecular Diagnostics·Moritz MaasTilman Todenhöfer
Nov 14, 2017·Current Urology Reports·Aaron Leiblich
Mar 12, 2019·Current Opinion in Urology·Abhishek Bhat, Chad R Ritch
Nov 24, 2018·World Journal of Urology·Izak FaienaHideki Furuya
Jan 13, 2018·International Journal of Molecular Sciences·Jan GleichenhagenGeorg Johnen
Jun 4, 2020·Cancers·Manuel Castanheira de OliveiraRicardo Ribeiro
Dec 31, 2020·Scandinavian Journal of Urology·Tammer HemdanPer-Uno Malmström
May 28, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Jorge Luis WilsonHatylas Azevedo

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