PMID: 7156853Sep 1, 1982

Evaluation of a new semiautomatic electrode system for simultaneous measurement of ionized calcium and pH

Scandinavian Journal of Clinical and Laboratory Investigation
J ThodeO Siggaard-Andersen

Abstract

The instrument (ICA 1 Radiometer, Copenhagen) measures the activity of calcium ion and hydrogen ion and displays the estimated concentration of free calcium ion (cCa2+) and pH at 37 degrees C in 110 microliter of whole blood or serum. The cCa2+ at pH 7.40 is calculated by means of a fixed relationship between cCa2+ and pH. The results are indicated on a display approximately 1 min after sample introduction. The measuring cycle plus automatic rinsing takes 3 min. The apparatus is equipped with a number of control functions. The sensitivity of the calcium electrode showed a fall from 100% to 92% over 20 weeks. The cell potential of the calcium cell showed a slow drift of--0.02 mV per day over a 20-week period while the pH cell which employs the same reference electrode showed no drift. Interference of Na+, K+, Li+, Mg2+ and H+ on the calcium measurement in whole blood is estimated to be at most +0.1%. The effect of erythrocytes on the static liquid junction potential is minimized by a special extrapolation procedure. The analytical standard deviation for cCa2+ in serum was 0.008 mmol/l within series, 0.017 mmol/l between days. The mean value for cCa2+ (at pH 7.4) in serum for 53 healthy adults was 1.249 mmol/l with a standard dev...Continue Reading

References

Feb 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T C PengR P Kusy
Oct 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J H Ladenson
Feb 1, 1987·Calcified Tissue International·N EidelmanW E Brown
Sep 1, 1985·Calcified Tissue International·B LundO H Sørensen
Jul 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C KancirJ Wandrup
Jun 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·N Fogh-AndersenJ Thode
Jul 29, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·C KancirA S Olesen
May 31, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Elise KlæstrupSøren Risom Kristensen
Oct 1, 1991·Bone and Mineral·S C GarnerI Parikh
May 1, 1987·Acta Anaesthesiologica Scandinavica·C KancirJ Wandrup
Sep 29, 2009·Clinical Science·Henrik DimkeRené J Bindels
Feb 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·J WandrupB Nørgaard-Pedersen
Sep 1, 1992·Scandinavian Journal of Primary Health Care·G LindstedtR Eggertsen
Aug 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S C GarnerS U Toverud
Jun 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S C GarnerS U Toverud
Jun 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·J Thode
Apr 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·J ThodeO Siggaard-Andersen
Oct 1, 1994·Journal of the American College of Nutrition·F Mimouni, R C Tsang
May 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·A UldallT Weber
Apr 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·J ThodeO Siggaard-Andersen

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Calcium [EPC]
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