PMID: 591638Nov 1, 1977

Evaluation of a new test system for rubella haemagglutination inhibiting antibodies

Journal of Clinical Pathology
P C Roberts, S J Hobbs

Abstract

A recently available kit for the determination of rubella haemagglutination inhibiting antibodies (Rubindex, Ortho diagnostics) was was compared with the method used routinely in this laboratory. Rubindex compared favourably in that no significant difference in titre was found in 95.1% of 287 sera tested. Difficulty occurred with some sera from cases of Mycoplasma pneumoniae infection, rheumatoid arthritis, and a small number of normal sera containing human "O" cell agglutinins. This was overcome by treatment of the sera with 2-mercaptoethanol. Rubindex had the advantage that all reagents were provided in kit form and the trypsinised human "O" cells provided had a longer shelf life than chick erythrocytes.

References

Dec 9, 1967·Lancet·I H Holms, M F Warburton
Jan 1, 1974·Archiv für die gesamte Virusforschung·S IwakataN A Labzoffsky
Oct 1, 1973·Journal of Clinical Pathology·C M Bannerman, C A Ross
Mar 9, 1967·The New England Journal of Medicine·G L StewartH M Meyer
May 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·P E HalonenJ A Stewart

Related Concepts

Antibodies, Viral
False Positive Reactions
Hemagglutination Inhibition Tests
IgM2
Eperythrozoonosis
Rubella

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