Evaluation of a New Topical Treatment for the Control of Cutaneous Leishmaniasis

Microorganisms
Berenice Martínez-SalazarFabienne Tacchini-Cottier

Abstract

Leishmania major (L. major) causes cutaneous leishmaniasis in the Old World. The infection mostly induces a localized lesion restricted to the sand fly bite. The costs and the side effects of current treatments render imperative the development of new therapies that are affordable and easy to administrate. Topical treatment would be the ideal option for the treatment of cutaneous leishmaniasis. MF29 is a 3-haloacetamidobenzoate that was shown in vitro to inhibit tubulin assembly in Leishmania. Here, we tested a topical cream formulated with MF29. BALB/c mice were infected in the ear dermis with L. major metacyclic promastigotes and once the lesion appeared, mice were treated with different concentrations of MF29 and compared to the control group treated with the cream used as the vehicle. We observed that topical application of MF29 reduced the progression of the infection while control groups developed an unhealing lesion that became necrotic. The treatment decreased the type 2 immune response. Comparison with SinaAmphoLeish, another topical treatment, revealed that MF29 treatment once a day was sufficient to control lesion development, while application SinaAmphoLeish needed applications twice daily. Collectively, our data su...Continue Reading

References

Nov 5, 2002·Nature Reviews. Immunology·David Sacks, Nancy Noben-Trauth
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles F AndersonDavid L Sacks
Aug 22, 2006·Journal of Enzyme Inhibition and Medicinal Chemistry·Abdala HiamPatrice Le Pape
Feb 7, 2007·The Journal of Experimental Medicine·Charles F AndersonDavid Sacks
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nicola KimblinDavid Sacks
Jun 14, 2012·PloS One·Jorge AlvarUNKNOWN WHO Leishmaniasis Control Team
Feb 8, 2013·The New England Journal of Medicine·Afif Ben SalahMax Grogl
Apr 20, 2014·Journal of Travel Medicine·Johannes BlumDiana N J Lockwood
Jun 7, 2014·Frontiers in Cellular and Infection Microbiology·Steffen SchusterCatherine Ronet
Feb 18, 2015·American Journal of Clinical Dermatology·Henry J C de VriesHenk D F H Schallig
May 29, 2015·PLoS Pathogens·Benjamin P HurrellFabienne Tacchini-Cottier
May 28, 2016·The Journal of Pharmacy and Pharmacology·Katrien Van BocxlaerSimon L Croft
Jul 19, 2016·Nature Reviews. Immunology·Phillip Scott, Fernanda O Novais
Mar 17, 2018·BMC Public Health·Issam BennisMarleen Boelaert
Aug 22, 2018·Lancet·Sakib BurzaMarleen Boelaert
Dec 31, 2018·The Journal of Investigative Dermatology·Catherine RonetFabienne Tacchini-Cottier
Feb 26, 2019·PLoS Neglected Tropical Diseases·Freddie BaileyDavid H Molyneux
May 3, 2019·PLoS Neglected Tropical Diseases·Néstor SosaMax Grogl
Jul 20, 2019·International Journal for Parasitology. Drugs and Drug Resistance·Diana CaridhaSimon L Croft
Oct 5, 2019·International Journal for Parasitology. Drugs and Drug Resistance·Mahmoud Reza JaafariAli Khamesipour
Feb 29, 2020·Nature Reviews. Molecular Cell Biology·Carsten Janke, Maria M Magiera

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Methods Mentioned

BETA
FCS
FACS
flow cytometry
ELISA

Software Mentioned

SinaApholeish
Prism GraphPad
FlowJo
DIVA

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