Evaluation of a non-chlorofluorocarbon formulation of cromolyn sodium (Intal) metered-dose inhaler versus the chlorofluorocarbon formulation in the treatment of adult patients with asthma: a controlled trial

The Journal of Allergy and Clinical Immunology
M N BlumenthalF E Casty

Abstract

Cromolyn sodium is a nonsteroidal inhaled antiinflammatory agent for the treatment of asthma. As with other pressurized aerosol medications, the metered-dose inhaler (MDI) formulation currently contains chlorofluorocarbon (CFC) propellants. Because of their harmful effects on the environment CFCs are now generally banned from production and use. Alternative propellants under production for MDIs include derivatives of hydrofluoroalkane (HFA). This study uses HFA-227 in an MDI formulation of cromolyn sodium. The objectives of the study were (1) to examine the efficacy and safety of an HFA formulation of cromolyn sodium (Intal) MDI and (2) to compare the HFA formulation with the CFC formulation. A multicenter, randomized, double-blind, placebo-controlled, parallel study with two active groups (HFA-cromolyn sodium [n = 113] and CFC-cromolyn sodium [n = 107]) and a placebo-treated group (n = 105). Patients treated with either formulation of cromolyn sodium MDI showed a statistically significant (p < 0.05) improvement of 12% to 18% compared with placebo in symptom summary score, daytime asthma symptoms, and albuterol use. No statistically significant differences were observed in pulmonary function. Patient and physician opinions of o...Continue Reading

References

Nov 1, 1991·The Journal of Allergy and Clinical Immunology·G G ShapiroC W Bierman
Mar 1, 1989·The American Review of Respiratory Disease·T L PettyR Oakley
Jan 3, 1996·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·I J Smith
Jan 3, 1996·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·T J Noakes

❮ Previous
Next ❯

Citations

Mar 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mary Lee-WongYoshiko Ogawa
Nov 22, 2005·Expert Opinion on Drug Delivery·Hugh D C Smyth
Sep 18, 2014·Journal of Pharmaceutical Sciences·William H DoubDiem Ngo
Nov 9, 2000·Regulatory Toxicology and Pharmacology : RTP·P Baldrick
Aug 13, 2005·Respiratory Medicine·Yasuyuki SanoTerumasa Miyamoto
Jan 13, 2006·Journal of Pediatric Psychology·Avani C Modi, Alexandra L Quittner
Apr 28, 2011·Journal of Veterinary Pharmacology and Therapeutics·J M SallovitzC E Lanusse

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Human & Experimental Toxicology
D J Alexander, S E Libretto
Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
D J Alexander
© 2021 Meta ULC. All rights reserved