Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis

Bioanalysis
Jinming XingArkady I Gusev

Abstract

Aim: Evaluation of a novel microsampling device for its use in clinical sample collection and biomarker analysis. Methodology: Matching samples were collected from 16 healthy donors (ten females, six males; age 42 ± 20) via K2EDTA touch activated phlebotomy (TAP) device and phlebotomy. The protein profile differences between sampling groups was evaluated using aptamer-based proteomic assay SomaScan and selected ELISA. Conclusion: Somascan signal concordance between phlebotomy- and TAP-generated samples was studied and comparability of protein abundances between these blood sample collection methods was demonstrated. Statistically significant correlation in selected ELISA assays also confirmed the TAP device applicability to the quantitative analysis of protein biomarkers in clinical trials.

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Citations

Oct 25, 2020·The AAPS Journal·Enaksha R WickremsinheBrian P Booth
Nov 25, 2020·Nature Medicine·Christopher A JamesMelanie D Anderson
Jan 21, 2021·Therapeutic Drug Monitoring·Lisa DelahayeChristophe Stove
Jun 6, 2021·Drug Testing and Analysis·Madhura Rajadhyaksha, Vaishali Londhe

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Methods Mentioned

BETA
blood draws
blood drawn
blood draw
ELISA
PCA
blood drawing
blood collection
proteome

Software Mentioned

SOMAmers
Ella
Bioconductor
Limma
Excel
R
SomaLogic
arrayQualityMetrics
Simple Plex Explorer
SOMAmer

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