Evaluation of a novel polihexanide-preserved wound covering gel on dermal wound healing

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
O GoertzS Langer

Abstract

Daily wound assessment, including dressing changes and the removal of old ointments causes discomfort for the patient. We therefore developed a new thermoreversible and transparent gel formulation that allows for filling wounds of different shapes and depths. The aim of the study was to investigate the effect of a wound covering gel on wound healing and the skin's microcirculation. Investigations were carried out in a standardized and reproducible wound model (hairless mice SKH1/hr, n = 30). Three groups were studied by intravital fluorescence microscopy: treatment with polihexanide-preserved wound covering gel, a formulation containing 3% povidone (PVP)-iodine, and physiological saline for control. Microcirculatory standard parameters were analysed. The non-perfused area vanished within 14 days due to angiogenesis. The venular diameter, oedema formation and functional capillary density showed no significant differences between the three groups. The use of the newly developed wound covering gel has no toxic effects on microcirculation and angiogenesis and reveals no significant differences in the overall assessment of microcirculation compared to the control group and the well-established PVP-iodine. The transparent antibacteri...Continue Reading

Citations

Jun 8, 2011·International Wound Journal·Ole GoertzHeinz H Homann
Mar 17, 2011·Annals of Plastic Surgery·Ole GoertzHeinz H Homann
Aug 28, 2021·Medical Sciences : Open Access Journal·Eberhard GrambowDaniel Strüder

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