PMID: 6399513Jan 1, 1983Paper

Evaluation of a parallel plate membrane plasma exchange system

Journal of Clinical Apheresis
G W BuffaloeP C Dau

Abstract

A new parallel plate membrane plasma exchange system (Centry TPE System) has been developed and clinically evaluated. A series of 27 consecutive plasma exchanges were performed on 14 patients with autoimmune diseases. Blood access was obtained by routine means identical to centrifugal procedures. The blood flow rate was 94 +/- 20 ml/min and plasma filtration rate was 37 +/- 9 ml/min, with an average patient hematocrit of 36%. The sieving coefficients for a wide range of plasma solutes including immunoglobulins, immune complexes, and lipids, clustered about 1.00, indicating nonselective plasma filtration. The average reduction in patient plasma solutes of 60 to 70% was in close agreement with the predicted value for unhindered plasma filtration. There was no appreciable loss of blood cells, as compared to a study with a centrifugal system showing a 56% reduction in circulating platelets. Complement activation measured by C'3 conversion was undetectable in patient samples and either undetectable or minimal in plasma filtrate samples. The system was convenient to operate and problems were rare. No untoward patient effects attributable to the membrane system were observed. These results show that the parallel plate membrane plasma ...Continue Reading

References

Sep 1, 1981·Transfusion·T B WiltbankL I Friedman
Jun 2, 1980·Klinische Wochenschrift·H G SieberthP Mathieu

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Citations

Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·E Patten
Jan 1, 1983·Journal of Clinical Apheresis·P C Dau
Jan 1, 1988·Journal of Clinical Apheresis·G D AntwilerD D Lobdell
Nov 29, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G A Siami, F S Siami
Jan 1, 1983·Journal of Clinical Apheresis·L GrossmanG W Buffaloe

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