Evaluation of a perforated drug delivery system in mice for prolonged and constant release of a hydrophilic drug

Drug Delivery and Translational Research
Ashish RastogiSalomon Stavchansky

Abstract

A drug delivery system (DDS) consisting of a perforated microtube (polyimide, inside diameter = 1.8 mm, tube length = 20 mm, hole size = 0.15 mm) was characterized in vitro and in vivo for its usefulness for long-term release of hydrophilic drugs at a constant rate. Sodium fluorescein mixed with stearic acid was used as the model drug. The DDS was packed with sodium fluorescein and stearic acid in ratios of 50:50, 40:60, and 25:75, respectively, and in vitro drug release studies were performed in saline. Linear release rates with R (2) > 0.9700 were obtained for all groups. Release rates of 1,077.3 ± 264.6, 342.6 ± 146.4, and 14.4 ± 7.0 μg/day for sodium fluorescein were obtained from the three groups, respectively. After monitoring the in vitro release of fluorescein for 11 days, 7 tubes from the 40:60 group were implanted subcutaneously in each individual mice to study the in vivo release of fluorescein from the tubes by measuring the fluorescein in the urine for 84 days. An initial rapid release during the first 4 days was followed by a near zero order fluorescence from the tubes (R (2) = 0.9870). Following completion of the study, the DDSs were retrieved for histology. Morphological analysis indicated no clinical adverse re...Continue Reading

References

Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·V R Sinha, Aman Trehan
Dec 19, 2003·Expert Opinion on Biological Therapy·Neelesh K Varde, Daniel W Pack
Sep 26, 2006·Drug Discovery Today·Mariko Morishita, Nicholas A Peppas
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
May 11, 2007·Expert Opinion on Drug Delivery·Jaleh Varshosaz
Mar 6, 2008·Expert Opinion on Drug Delivery·Frauke KreyeJuergen Siepmann
Aug 30, 2008·Expert Opinion on Drug Delivery·Frances E KaneKenneth E Green
Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kinga Musiał, Danuta Zwolińska
Feb 25, 2011·Biomedical Microdevices·Zhuo-Jie WuPaul S Ho
Mar 5, 2011·Journal of Pharmaceutical Sciences·Divyakant DesaiLaxmikant Sharma
Sep 14, 2011·Transplantation·Josep M CampistolChristophe Legendre

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Citations

Feb 1, 2015·International Journal of Pharmaceutics·Laurent Simon, Juan Ospina
Jul 6, 2016·International Neurourology Journal·Seung Ho Lee, Young Bin Choy
Feb 16, 2008·Drug Discovery Today·Eva M Del Amo, Arto Urtti

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