Abstract
Control measures for H5N1 avian influenza involve increased biosecurity, monitoring, surveillance and vaccination. Subclinical infection in farmed ducks is important for virus persistence. In major duck rearing countries, homologous H5N1 vaccines are being used in ducks, so sero-surveillance using H5- or N1-specific antibody testing cannot identify infected flocks. An alternative is to include a positive marker for vaccination. Testing for an antibody response to the marker would confirm approved vaccine use. Concurrent testing for H5 antibody responses would determine levels adequate for protection or indicate recent infection, with an anamnestic H5 antibody response requiring further virological investigation. In this study, we have evaluated the use of a TT marker in ducks given avian influenza vaccination. Wild or domestic ducks were tested for antibodies against TT and all 463 ducks were negative. High levels of TT-specific antibodies, produced in twice-TT vaccinated Muscovy ducks, persisted out to 19 weeks. There was no interference by inclusion of TT in an inactivated H6N2 vaccine for H6- or TT-seroconversion. Thus TT is a highly suitable exogenous marker for avian influenza vaccination in ducks and allows sero-surveilla...Continue Reading
References
Nov 15, 2002·Avian Pathology : Journal of the W.V.P.A·David A Halvorson
Apr 14, 2004·Journal of Virology·Katharine M Sturm-RamirezRobert G Webster
Jul 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·D J Hulse-PostR G Webster
Aug 9, 2005·The Veterinary Record·L D SimsP Roeder
Sep 17, 2005·Animal Health Research Reviews·Chang-Won Lee, David L Suarez
Nov 1, 2005·Biologicals : Journal of the International Association of Biological Standardization·David L Suarez
Feb 24, 2006·Emerging Infectious Diseases·Marius GilbertJan Slingenbergh
May 18, 2006·Emerging Infectious Diseases·Thaweesak SongsermRobert G Webster
Jun 7, 2006·Avian Pathology : Journal of the W.V.P.A·Ilaria Capua, Dennis J Alexander
Nov 1, 2006·Emerging Infectious Diseases·Ilaria Capua, Stefano Marangon
Nov 7, 2006·Emergency Medicine Australasia : EMA·Alan W Hampson
Mar 14, 2007·The Veterinary Record·A MartinotN Dasgupta
May 15, 2007·Avian Diseases·J A van der GootG Koch
Jun 23, 2007·Vaccine·Cassandra M JamesTrevor M Ellis
Jan 1, 2007·Influenza and Other Respiratory Viruses·Ilaria Capua, Dennis J Alexander
Citations
Jan 1, 2010·Influenza Research and Treatment·Tze-Hoong ChuaTrevor M Ellis
Jun 28, 2011·Virology Journal·Chun G LiuWen H Xiang
Feb 14, 2013·Avian Diseases·David L Suarez
Feb 14, 2013·Avian Diseases·Helena Lage FerreiraBénédicte Lambrecht
May 19, 2009·Molecular Immunology·Qunfeng WuShaobo Xiao
Jan 25, 2011·The Veterinary Record·C M James-BerryT M Ellis
Dec 29, 2020·Veterinary World·Jossie Intan CahyaniMichael Haryadi Wibowo