PMID: 3975223Jan 1, 1985

Evaluation of a prenatal screening procedure for beta-thalassaemia carriers in a Chinese population based on the mean corpuscular volume (MCV)

Prenatal Diagnosis
A GhoshT K Chan

Abstract

Haemoglobin A2 (HbA2) levels were determined on 25 beta-thalassaemia carriers by the microcolumn method and were found to range from 4.5-7.2 per cent (mean 5.2 +/- 0.82 S.D.). The haemoglobin level (Hb), mean corpuscular volume (MCV), plasma ferritin and HbA2 levels were measured on a further 299 consecutive Chinese pregnant women at a gestation of less than 24 weeks. 18 patients (6 per cent) had HbA2 level greater than 4.5 per cent and were diagnosed to be beta-thalassaemic carriers. It was observed that all these patients had a MCV below 75 fl. If this level is selected in a screening procedure based on measurement of MCV alone all beta-thalassaemia carriers could be detected and 11 per cent of the population screened would require HbA2 estimation. At a lower cut-off level of 70 fl, 8 per cent of the population screened would require HbA2 measurement (a decrease of 27 per cent) but the detection rate will be lowered considerably (83 per cent). The high false positive rate at all cut-off levels of MCV was largely due to the prevalence of iron deficiency anaemia in the population. Estimation of plasma ferritin level in patients with low MCV will reduce this false positive rate, but there will be a considerable delay in diagnosi...Continue Reading

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Citations

Jan 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W HolzgreveJ Horst
Dec 1, 1990·Journal of Paediatrics and Child Health·A M Li, M Y Cheng
Apr 24, 2002·Archives of Disease in Childhood·C K LiP M P Yuen
Jun 1, 1990·Journal of Medical Genetics·A S ChauA Ghosh
Jul 6, 2014·Human Immunology·Eirini KontakiotiMichail Daniilidis
Jan 1, 1988·Hemoglobin·G P TamagniniW K Fai
Mar 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K N LaiS F Lui
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Jan 1, 1990·Free Radical Research Communications·R I Zhdanov, P G Komarov
Jul 14, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Mar 1, 1989·Archives of Disease in Childhood·O StarkC Moynihan
Jun 6, 1998·Pediatric Hematology and Oncology·A C LeeK T So
Feb 1, 2018·Current Medical Research and Opinion·Amani M Al-AmodiJ Francis Borgio

Related Concepts

Mean Corpuscular Hemoglobin Concentration Determination
False Positive Reactions
Isoferritin
Genetic Screening Method
Hemoglobin A2
Heterozygote Detection
Pregnancy Complications
Antenatal Screening Procedures
Thalassemia

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