Evaluation of a pseudo-one-compartment model for phosphorus kinetics by later-phase dialysate collection during blood purification

The International Journal of Artificial Organs
Masatomo YashiroRumi Sakai

Abstract

Phosphorus removal is a major issue to assess for physicians engaging in hemodialysis. A pseudo-one-compartment model was reported as a novel model for phosphorus kinetics. We aimed to evaluate the adequacy of this model from the standpoint of the total mass of removed phosphorus during prolonged treatment. Dialysate was collected during 6-h hemodialysis and hemodiafiltration treatment in 5 patients. Later-phase (from 4 to 6 h) dialysate was collected separately. Mobilization clearance (K(m)) and dialyzer clearance (K) were calculated by simple arithmetic operations utilizing stable serum phosphorus concentrations in this later phase. Volume of the accessible compartment (V(0)) was estimated by a fitting method. Amounts of removed phosphorus were calculated with these parameters and compared with measured values. The best sampling time points during treatment were also assessed, when the parameters were determined by serial serum phosphorus concentrations alone. Pearson's correlation coefficient (R) between calculated and measured values of removed phosphorus was 0.991 and the concordance correlation coefficient (ρ) was 0.987. When K(m), K and V(0) were determined by serial serum concentrations alone, including those at 0, 1, 4...Continue Reading

References

Feb 19, 2002·Kidney International·Elaine M SpaldingKen Farrington
Jun 3, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca TentoriFriedrich K Port
Jan 23, 2010·Blood Purification·Martin K Kuhlmann
Oct 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Baris U AgarJohn K Leypoldt
Mar 21, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesca TentoriBruce Robinson
May 12, 2012·Hemodialysis International·Baris U AgarJohn K Leypoldt
Mar 15, 2013·Blood Purification·John K LeypoldtBruce F Culleton
May 30, 2013·Kidney International·John K LeypoldtBruce F Culleton

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Citations

Mar 5, 2020·The International Journal of Artificial Organs·John K LeypoldtJacek Waniewski

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