Evaluation of a pulsed xenon ultraviolet disinfection system for reduction of healthcare-associated pathogens in hospital rooms

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Michelle M NerandzicCurtis J Donskey

Abstract

OBJECTIVE To determine the effectiveness of a pulsed xenon ultraviolet (PX-UV) disinfection device for reduction in recovery of healthcare-associated pathogens. SETTING Two acute-care hospitals. METHODS We examined the effectiveness of PX-UV for killing of Clostridium difficile spores, methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) on glass carriers and evaluated the impact of pathogen concentration, distance from the device, organic load, and shading from the direct field of radiation on killing efficacy. We compared the effectiveness of PX-UV and ultraviolet-C (UV-C) irradiation, each delivered for 10 minutes at 4 feet. In hospital rooms, the frequency of native pathogen contamination on high-touch surfaces was assessed before and after 10 minutes of PX-UV irradiation. RESULTS On carriers, irradiation delivered for 10 minutes at 4 feet from the PX-UV device reduced recovery of C. difficile spores, MRSA, and VRE by 0.55±0.34, 1.85±0.49, and 0.6±0.25 log10 colony-forming units (CFU)/cm2, respectively. Increasing distance from the PX-UV device dramatically reduced killing efficacy, whereas pathogen concentration, organic load, and shading did not. Continuous UV-C achieved signific...Continue Reading

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Jan 27, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jennifer L CadnumCurtis J Donskey
Oct 22, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Dana RussellDaniel Z Uslan
Mar 24, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·John M BoyceMichael Aniskiewicz
Apr 14, 2016·Antimicrobial Resistance and Infection Control·John M Boyce
Aug 10, 2015·American Journal of Infection Control·Gabriele MessinaGabriele Cevenini
Jul 15, 2015·American Journal of Infection Control·Aarathi NagarajaMarisa A Montecalvo
Aug 9, 2015·Current Infectious Disease Reports·Michelle DollGonzalo Bearman
Apr 23, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Philip C Carling
Feb 28, 2016·American Journal of Infection Control·J Itty MathewCurtis J Donskey
May 1, 2016·American Journal of Infection Control·William A Rutala, David J Weber
Jul 23, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michelle M Nerandzic, Curtis J Donskey
Aug 16, 2016·Infectious Disease Clinics of North America·Philip C Carling
Aug 16, 2016·Infectious Disease Clinics of North America·William A Rutala, David J Weber
Jan 6, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Venkata C K SunkesulaCurtis J Donskey
Jan 6, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Tânia ClaroHilary Humphreys
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Sep 19, 2018·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jennifer BriteMini Kamboj
Jan 31, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jennifer L CadnumCurtis J Donskey
Jun 9, 2016·Current Opinion in Infectious Diseases·Stephanie J Dancer
Jun 4, 2016·Current Opinion in Infectious Diseases·David J WeberWilliam A Rutala
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