Evaluation of a resorbable, in situ setting bone substitute in a sheep model

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Christopher NiedhartChristian H Siebert

Abstract

The gold standard for bone substitution is the autologous bone graft, but because of its limited supply and the associated morbidity, the search for synthetic alternatives is necessary. A new in situ setting tricalcium phosphate cement was implanted in a trepanation defect (9.4 mm diameter, 10 mm depth) in the distal femoral epiphysis of sheep. Empty cavities and autologous bone graft were used as controls. Histologic and histomorphometric examinations were carried out after 12 weeks. Nearly 90% of the implanted cement was resorbed and replaced by ingrown bone with close contact between surrounding bone, new bone, and remaining cement particles. The amount of bone in the defect area was significantly higher in defects filled with cement relative to defects filled with autologous bone graft (mean 27 vs. 21%, 95% confidence intervals 23 to 31 and 18 to 23, p = 0.026). In conclusion, this new in situ setting cement is bioactive, resorbable, and osteoconductive. It will be useful as an alternative to autologous bone graft to fill stable defects.

References

Jan 1, 1989·Journal of Biomedical Materials Research·T N GerhartW C Hayes
Mar 24, 1995·Science·B R ConstantzD I Rosenthal
Nov 1, 1993·Calcified Tissue International·M F BasléA Rebel
Jun 1, 1997·Clinical Orthopaedics and Related Research·J A GouletM L Greenfield
Jun 26, 1998·Journal of Biomedical Materials Research·S J PeterA G Mikos
Sep 8, 1998·The Journal of Bone and Joint Surgery. American Volume·E P FrankenburgR D Poser
Oct 27, 1998·Journal of Biomedical Materials Research·A DuprazN Passuti
Dec 17, 1998·Journal of Biomedical Materials Research·D KnaackD D Lee
Feb 19, 2000·Journal of Biomedical Materials Research·P FrayssinetN Rouquet
Apr 5, 2001·Journal of Biomedical Materials Research·C NiedhartC H Siebert
May 11, 2002·The Journal of Bone and Joint Surgery. American Volume·Elke AhlmannPaul Holtom

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Citations

Mar 12, 2008·Archives of Orthopaedic and Trauma Surgery·Uwe MausChristopher Niedhart
Aug 19, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Uwe MausChristopher Niedhart
Jul 19, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ming DingSøren Overgaard
Jul 7, 2010·Journal of Tissue Engineering and Regenerative Medicine·Liliana OfferReinhard Schnettler
Sep 13, 2006·International Journal of Oral and Maxillofacial Surgery·B SinikovićR Dempf
Jan 16, 2008·Journal of Biomaterials Applications·Uwe MausChristian H Siebert
Dec 1, 2006·Sports Medicine and Arthroscopy Review·Gabriele G NiederauerSwetha Sankaran
Oct 8, 2009·Bioscience, Biotechnology, and Biochemistry·Shi-Wu DongJian-Sen Sun
Nov 10, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·G X NiK D K Luk

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