Evaluation of a single-stage consumable-free modulator for comprehensive two-dimensional gas chromatography: analysis of polychlorinated biphenyls, organochlorine pesticides and chlorobenzenes

Journal of Chromatography. a
Alina M MuscaluEric J Reiner

Abstract

Comprehensive two-dimensional gas chromatography (GC×GC) has been rapidly growing in popularity. The GC×GC separation is performed by interfacing a modulator between two columns of different selectivities. The modulator periodically traps and then re-injects the analytes eluting from the first column into the second column. The most popular GC×GC systems require consumables such as liquid N2 for the trapping function of the modulator. Although these systems are very effective, their costs are a hindrance to more widespread use. A new, single-stage thermal modulator for GC×GC that requires no consumables has been developed and tested. The device traps analytes using a proprietary stainless steel capillary trap compressed between two ceramic cooling pads. Analytes are thermally desorbed from the trap into the second column via resistive heating. To evaluate this system, a routine accredited method for the analysis of polychlorinated biphenyls, organochlorine pesticides and chlorobenzenes was run using the new modulator and its performance was compared to that of an industry standard modulation system. Within-day repeatability (% RSD ranging from 2% to 13%), between-day reproducibility (% RSD from 3% to 15%), as well as between-tr...Continue Reading

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Citations

Aug 19, 2016·Analytical Chemistry·Jim LuongRobert A Shellie
Dec 1, 2017·Critical Reviews in Analytical Chemistry·Tomasz Dymerski
Jan 11, 2020·Critical Reviews in Analytical Chemistry·John Mommers, Sjoerd van der Wal
Feb 18, 2021·Journal of Separation Science·Barbara GiocastroLuigi Mondello
Aug 2, 2017·Analytical Chemistry·Hei-Yin J Chow, Tadeusz Górecki

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