PMID: 16641539Apr 28, 2006Paper

Evaluation of a two-generation reproduction toxicity study adding endpoints to detect endocrine disrupting activity using lindane

The Journal of Toxicological Sciences
Ikuo MatsuuraYasuo Ikeda

Abstract

A two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using lindane by dietary administration at 0, 10, 60, and 300 ppm, for investigation of its utility. The extra endpoints included anogenital distance (AGD), nipple development, sexual maturation (vaginal opening and preputial separation), estrous cycle, spermatogenesis, sex organ weights, and blood hormone concentrations (thyroid and sex hormones). F1 offspring were examined for emotionality (open field test), motor coordination (rotarod test), as well as learning and memory (pole-climbing test). Hepatic drug-metabolizing enzyme activities were also measured. The results revealed general toxicological effects on parental animals, influence on reproductive function, and altered development of offspring; however, they did not demonstrate any distinct changes in the extra endpoints for detection of endocrine disrupting activity. Adult toxicity was observed in both F0 and F1 animals, including suppressed body weight gain and reduced food consumption in both sexes, and deaths of females at 300 ppm. Convulsions and irritability were observed during the perinatal period in pregnant F1 females given 300 ppm....Continue Reading

References

Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
May 1, 1990·Toxicology and Applied Pharmacology·L D Lehman-McKeemanD Caudill
Oct 1, 1991·Bulletin of Environmental Contamination and Toxicology·K SrinivasanR Radhakrishnamurty
Mar 30, 1987·Toxicology and Applied Pharmacology·H A TilsonR L McLamb
Jan 1, 1988·Journal of Biochemical Toxicology·R W ChadwickW K McElroy
Jan 1, 1989·Toxicology and Applied Pharmacology·J A SwenbergM Charbonneau
Jul 1, 1989·Toxicology and Applied Pharmacology·R L CooperW K McElroy
Jul 1, 1989·Toxicology Letters·L Uphouse, J Williams
Jun 15, 1989·Toxicology and Applied Pharmacology·R M McClainJ C Downing
Jan 1, 1974·Internationales Archiv Für Arbeitsmedizin·I Dési
Jan 1, 1969·Psychopharmacologia·P C DandiyaS K Patni
Dec 1, 1968·Journal of Reproduction and Fertility·T Pedersen, H Peters
May 1, 1980·Journal of Toxicology and Environmental Health·R B RaizadaT S Dikshith
May 1, 1995·Environmental Health Perspectives·C F FacemireL J Guillette
May 1, 1996·Human & Experimental Toxicology·P R DalsenterI Chahoud
Nov 5, 1997·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B BolonJ J Heindel
Aug 1, 1997·Regulatory Toxicology and Pharmacology : RTP·J AshbyA N Brooks
May 15, 1998·Neurotoxicology and Teratology·S RiveraC Sanfeliu
May 4, 1999·Journal of Occupational and Environmental Medicine·L E FlemingK Hamilton
Feb 28, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Li YouHenry d'A Heck Hd
Mar 14, 1957·Annals of the New York Academy of Sciences·L COOK, E WEIDLEY
Jul 1, 1950·Proceedings of the Society for Experimental Biology and Medicine·E A DOISY, B C BOCKLAGE
Mar 2, 2005·Toxicology Letters·Kanji YamasakiSatoko Sakamoto
Jul 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·E A DOISY, B C BOCKLAGE

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Citations

Jul 21, 2011·Journal of Pharmacology & Pharmacotherapeutics·S Parasuraman
Jun 27, 2009·Journal of Applied Toxicology : JAT·Emma Di ConsiglioEmanuela Testai
Feb 7, 2020·International Journal of Environmental Research and Public Health·Claire Fong-McMasterAnne Tm Konkle
Mar 24, 2021·Environmental Science and Pollution Research International·Emilie MauduitJoël Meunier
May 22, 2019·Frontiers in Neuroendocrinology·Matthieu KellerThierry D Charlier
Jun 13, 2008·Theriogenology·J VerstegenK Verstegen-Onclin

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