PMID: 16641540Apr 28, 2006Paper

Evaluation of a two-generation reproduction toxicity study adding endpoints to detect endocrine disrupting activity using vinclozolin

The Journal of Toxicological Sciences
Ikuo MatsuuraMinoru Tsuchitani

Abstract

A two-generation reproduction toxicity study in rats adding extra endpoints to detect endocrine disrupting activity was conducted using vinclozolin by dietary administration at 0, 40, 200, and 1000 ppm, for investigation of its utility. The extra endpoints included anogenital distance (AGD), nipple development, sexual maturation (vaginal opening and preputial separation), estrous cycle, spermatogenesis, sex organ weights, and blood hormone concentrations (thyroid and sex hormones). Hepatic drug-metabolizing enzyme activities were also measured. The results revealed changes due to vinclozolin in the AGD, nipple development, sexual maturation, sex organ weights, and blood sex hormone concentrations in males of both parental animals and offspring, even at the lowest dose of 40 ppm, confirmed by results for the classical endpoints of histopathological examination at 200 ppm and mating at 1000 ppm. The effects on parental males included increased pituitary and testis weights, and decreased epididymis weights at 1000 ppm in both generations, and decreased prostate and epididymis weights at 200 and 1000 ppm and seminal vesicle weights at 1000 ppm in F1 males. Histopathological examination revealed hypertrophy of the basophilic cells i...Continue Reading

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Citations

Dec 7, 2006·Environmental Health : a Global Access Science Source·Gunnar ToftJens Peter Bonde
Nov 12, 2013·Hormones and Behavior·Panida LoutchanwootHubertus Jarry
Jan 29, 2010·Journal of Toxicology·Ray A MatulkaGeorge Burdock
Apr 26, 2015·Regulatory Toxicology and Pharmacology : RTP·Karen BlackburnKara Woeller
Sep 30, 2010·Regulatory Toxicology and Pharmacology : RTP·Steffen SchneiderBennard van Ravenzwaay
Mar 6, 2013·Asia-Pacific Journal of Public Health·Dilshad A KhanHizbullah Khan
Nov 22, 2013·Environmental and Molecular Mutagenesis·Rebecca A AlyeaReza J Rasoulpour
Sep 11, 2016·Archives of Toxicology·Burkhard FlickBennard van Ravenzwaay
Jul 7, 2020·EFSA Journal·UNKNOWN European Food Safety Authority (EFSA)Luc Mohimont
Jul 22, 2020·Endocrinology·Morgan E Hernandez ScudderAndrea C Gore
May 31, 2011·Regulatory Toxicology and Pharmacology : RTP·Susanne N KolleBennard van Ravenzwaay

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