Evaluation of a ureteral catheter coating by means of a BioEncrustation in vitro model

International Journal of Pharmaceutics
Marion FrantKlaus Liefeith

Abstract

Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the performance of biomaterials prior to performing delicate and expensive in vivo studies. In this study we present a complex BioEncrustation model that imitates both the processes of multi-species biofilm formation and encrustation in vitro. The resulting crystalline biofilms are compared to the deposits found on explanted ureteral stent surfaces (in vivo situation) and to deposits formed in an experimental set up that does not contain bacteria (Encrustator®). Further focus of this study is dedicated to employing the developed BioEncrustation model to evaluate the effect multifunctional coatings impose on the processes of biofilm formation and encrustation under in vitro conditions. The investigated TANP coating combines unspecific and broad band specific antibacterial properties with a degrading polymer matrix that is intended to inhibit crystal formation. The coating was prepared on both polyurethane and silicone tubes...Continue Reading

Citations

Apr 21, 2020·World Journal of Urology·Xiaopeng LiYongliang Ni
Apr 16, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Siriwan SrisangNorased Nasongkla
May 2, 2021·The Journal of Hospital Infection·A C IonescuR Mattina
Jun 1, 2021·ACS Omega·Buddhika GayaniManjula Manoji Weerasekera

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