Abstract
Autogenous veins are the materials of choice for arterial reconstruction. In the absence of autogenous material, prosthetic materials are used. However, vascular prostheses of less than 0.4 cm in diameter have low long-term patency. This study was designed to determine if cells would infiltrate an engineered xenogeneic biomaterial used as a small diameter arterial graft in dogs and, if so, to determine the phenotype of the infiltrating cells. Nine acellular xenogeneic grafts (0.4 cm in diameter, 5 cm long), composed of porcine collagen derived from the submucosa of the small intestine and type I bovine collagen, were implanted as end to-end interposition grafts in femoral arteries of five male mongrel dogs (total of nine grafts). All dogs received daily aspirin (325 mg). Patency of implanted grafts was monitored weekly by Duplex ultrasonography. After 9 weeks, or earlier in case of blood flow reduction by at least 75%, grafts were explanted and prepared for light or electron microscopy to evaluate cellularization. Eight of nine grafts remained patent up to 9 weeks. At explant, diameters were 0.31 +/- 0.02 cm at the midgraft, and 0.14 +/- 0.01 and 0.19 +/- 0.01 cm at the proximal and distal anastomoses. At explant, cells of mese...Continue Reading
Citations
Oct 27, 2007·Tissue Engineering·Jan P StegemannShaneen L Rowe
Nov 19, 2010·Tissue Engineering. Part a·Hao-Fan PengDaniel D Swartz
May 11, 2012·Tissue Engineering. Part B, Reviews·Vivek K Bajpai, Stelios T Andreadis
Apr 15, 2004·Annals of Surgery·T Wright JerniganTimothy C Fabian
Oct 19, 2011·Cells, Tissues, Organs·Haofan PengDaniel D Swartz
Aug 7, 2010·International Journal of Biomaterials·John C FitzpatrickFranco M Capaldi
Jan 12, 2010·Artificial Organs·Ji M Chang, Won G Kim
Dec 2, 2008·Journal of Cellular and Molecular Medicine·Dan LiaoChangyi Chen
Jul 16, 2010·Journal of Biomedical Materials Research. Part a·Jagannath DeyJian Yang
Apr 10, 2013·Artificial Organs·Yun XiongColin Song
Jun 8, 2012·Journal of Tissue Engineering and Regenerative Medicine·Hongjun KangQuanyi Guo
Feb 25, 2014·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Shunsuke SakakibaraHiroto Terashi
Feb 27, 2014·Asian Cardiovascular & Thoracic Annals·Balasundari RameshSoma Guhathakurta
Oct 6, 2017·Tissue Engineering. Part B, Reviews·Rui Han LiuNarutoshi Hibino
Mar 7, 2007·Medical & Biological Engineering & Computing·Sandip SarkarAlexander M Seifalian
Mar 9, 2007·World Journal of Surgery·Xinwen WangChangyi Chen
May 13, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ruben Y KannanAlexander M Seifalian
Mar 29, 2019·Stem Cells Translational Medicine·Ida SkovrindDitte Caroline Andersen
Sep 1, 2015·Cardiovascular Engineering and Technology·Aurore B Van de WallePeter S McFetridge
Feb 15, 2007·Artificial Organs·Xue-Ning WangY John Gu
Feb 23, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Juliana JaramilloJuan C Briceño
Feb 14, 2007·The International Journal of Artificial Organs·W S KimW G Kim
Apr 4, 2021·Cells·Shu FangDitte Caroline Andersen