Evaluation of abatacept in biologic-naïve patients with active rheumatoid arthritis.

Clinical Rheumatology
M H Schiff, Louis Bessette

Abstract

This article reviews the efficacy, safety, and tolerability of abatacept plus methotrexate in patients with active rheumatoid arthritis (RA) and an inadequate response to methotrexate who are naïve to biologic disease-modifying antirheumatic drugs (DMARDs). Data from the randomized, double-blind, placebo-controlled Abatacept in Inadequate Responders to Methotrexate, Abatacept or Infliximab vs Placebo, a Trial for Tolerability, Efficacy, and Safety in Treating Rheumatoid Arthritis, and phase IIb dose-finding trials and their long-term extensions are reviewed. Abatacept plus methotrexate significantly improved clinical responses, physical function, and health-related quality of life compared with methotrexate alone. More patients receiving abatacept plus methotrexate than methotrexate monotherapy achieved a low disease activity state or remission. Radiographic progression of the disease was significantly slowed in the abatacept plus methotrexate arms. Abatacept plus methotrexate was generally well tolerated with no clinically significant safety issues identified. The beneficial effects of abatacept plus methotrexate were sustained long term in extension studies, and no new tolerability or safety issues were evident. Abatacept in ...Continue Reading

References

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Citations

Sep 8, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B F RicciardiJ M Lane
Dec 19, 2015·Expert Review of Clinical Immunology·Maurizio CutoloCarmen Pizzorni
Jun 16, 2018·Experimental and Therapeutic Medicine·Xiu-Min ChenRun-Yue Huang
Jun 3, 2011·Arthritis Research & Therapy·Paul P Tak, Joachim R Kalden

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