Evaluation of acoustic radiation force impulse (ARFI) elastography as non-invasive diagnostic tool in living donor liver transplantation

Abdominal Radiology
Hanan AbdelhaleemAyman Yosry

Abstract

Role of acoustic radiation force impulse (ARFI) elastography, in transplant setting, is not well established. We aimed to define the normal mean values of the liver stiffness by ARFI Elastography in healthy liver donors and to evaluate ARFI elastography as predictor of graft fibrosis post living donor liver transplant (LDLT) in comparison to other non-invasive methods (transient elastography [TE], APRI and FIB4). A total of 100 subjects (70 recipients and 30 donors) were recruited. APRI and FIB4 scores were calculated for all recipients. TE and ARFI elastography (Siemens Acuson S2000 Ultrasound System, Germany) were performed to all subjects. All donors and only 30 recipients had liver biopsy. Significant fibrosis was defined as ≥ F2. The mean ARFI velocity among the donors was 1.05 ± 0.09 m/s. Regarding the recipients: mean age was 49.5 ± 8.49 years, 85.7% males, fibrosis stages < F2 were the most frequent stages by liver biopsy (86.7%) and TE (67.1%). ARFI median was significantly correlated with TE median, APRI and FIB-4 (r = 0.888, p = 0.000; r = 0.62, p = 0.000, and r = 0.585, p = 0.000, respectively). ARFI performed well in discriminating patients with ≥ F2 (AUROC = 0.93, 95% CI 0.86-0.99, p < 0.01) with best cutoff media...Continue Reading

References

Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Jul 11, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jose A CarriónXavier Forns
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C CorpechotR Poupon
Aug 2, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CorradiUNKNOWN Bologna Liver Transplantation Group
Oct 20, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·José A CarriónXavier Forns
Oct 31, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Hirokazu TakahashiKazuma Fujimoto
Mar 23, 2010·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·R S GoertzT Haendl
Jun 23, 2010·AJR. American Journal of Roentgenology·Mirko D'OnofrioRoberto Pozzi Mucelli
Jul 7, 2010·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·I SporeaA Tudora
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhong-Hua LinShi-Ying Xuan
Dec 6, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Corlan O AdebajoMichael R Charlton
Jan 25, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cristina RigamontiMaria Francesca Donato
May 1, 2012·Current Medical Imaging Reviews·Kathy Nightingale
Dec 25, 2012·Journal of Hepatology·Marina Berenguer, Detlef Schuppan
Apr 30, 2013·Diagnostic and Interventional Imaging·N Frulio, H Trillaud
Jul 19, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Simona BotaMarkus Peck-Radosavljevic
Oct 25, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Dane WildnerSteffen Zopf

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