Evaluation of adjuvant carboplatin chemotherapy in the management of surgically excised anal sac apocrine gland adenocarcinoma in dogs

Veterinary and Comparative Oncology
R M WoudaT Stein

Abstract

There is no widely accepted standard of care for canine anal sac apocrine gland adenocarcinoma (ASAGAC). Surgery alone is inadequate in many cases, but the benefit of adjuvant chemotherapy is not well established. The primary objective of this retrospective study was to evaluate the role of carboplatin chemotherapy in the post-operative management of ASAGAC. Seventy-four dogs with naturally occurring ASAGAC underwent surgery. Forty-four dogs received adjuvant carboplatin and 30 did not. Median overall survival (OS) was 703 days. Median time to progression (TTP) was 384 days. Only primary tumour size and lymph node metastasis at diagnosis significantly impacted the outcome. Differences in OS and TTP, between the dogs that received adjuvant carboplatin and those that did not, failed to reach statistical significance. Treatment of progressive disease, whilst not limited to chemotherapy, significantly prolonged the survival. This study shows that adjuvant carboplatin chemotherapy is well tolerated and may have a role in the management of dogs with ASAGAC.

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Citations

Mar 6, 2019·Journal of the American Veterinary Medical Association·Pierre M AmsellemBarbara E Powers
May 31, 2019·The Journal of Veterinary Medical Science·Sho YoshimotoTakayuki Nakagawa
Jan 22, 2020·The Journal of Small Animal Practice·A N SchlagB G Wustefeld-Janssens
Jan 25, 2020·Journal of Veterinary Internal Medicine·Caitlin M HeatonXuan Pan
Apr 9, 2020·Journal of Veterinary Internal Medicine·Hiroki YamazakiHideo Akiyoshi
Apr 9, 2020·Veterinary and Comparative Oncology·Aidan R ChambersBrandan G Wustefeld-Janssens
May 27, 2020·Veterinary and Comparative Oncology·Calli CoffeeMary Lynn Higginbotham
May 16, 2020·Journal of the American Animal Hospital Association·Shawna KlahnJonathan Abbott
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Emanuela Maria MorelloMarina Martano
Jun 27, 2021·Veterinary and Comparative Oncology·Allyson StermanBrandan Wustefeld Janssens
Nov 15, 2021·Veterinary and Comparative Oncology·Thomas ChavalleFrédérique Ponce

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