Evaluation of administration of isoflurane at approximately the minimum alveolar concentration on depression of a nociceptive withdrawal reflex evoked by transcutaneous electrical stimulation in ponies

American Journal of Veterinary Research
Claudia SpadavecchiaUrs Schatzmann

Abstract

To investigate effects of isoflurane at approximately the minimum alveolar concentration (MAC) on the nociceptive withdrawal reflex (NWR) of the forelimb of ponies as a method for quantifying anesthetic potency. 7 healthy adult Shetland ponies. Individual MAC (iMAC) for isoflurane was determined for each pony. Then, effects of isoflurane administered at 0.85, 0.95, and 1.05 iMAC on the NWR were assessed. At each concentration, the NWR threshold was defined electromyographically for the common digital extensor and deltoid muscles by stimulating the digital nerve; additional electrical stimulations (3, 5, 10, 20, 30, and 40 mA) were delivered, and the evoked activity was recorded and analyzed. After the end of anesthesia, the NWR threshold was assessed in standing ponies. Mean +/- SD MAC of isoflurane was 1.0 +/- 0.2%. The NWR thresholds for both muscles increased significantly in a concentration-dependent manner during anesthesia, whereas they decreased in awake ponies. Significantly higher thresholds were found for the deltoid muscle, compared with thresholds for the common digital extensor muscle, in anesthetized ponies. At each iMAC tested, amplitudes of the reflex responses from both muscles increased as stimulus intensities...Continue Reading

References

Jan 1, 1992·Pain·Daniel Le BarsThomas De Broucker
Sep 1, 1990·Equine Veterinary Journal·N S Matthews, S L Lindsay
Oct 1, 1980·Anesthesiology·A L QuashaJ H Tinker
Nov 1, 1993·Anesthesiology·S Petersen-FelixD A Thomson
Mar 11, 1999·Anesthesia and Analgesia·J F AntogniniV Buzin
Apr 20, 2002·Anesthesiology·Joseph F AntogniniRichard Atherley
Jun 28, 2003·American Journal of Veterinary Research·Claudia SpadavecchiaUrs Schatzmann
Nov 26, 2003·Anesthesiology·Omeed Sani, Steven L Shafer
Jun 2, 2005·Nature Reviews. Neuroscience·Rafael YusteAnders Lansner

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