Evaluation of adverse effects of long-term orally administered carprofen in dogs

Journal of the American Veterinary Medical Association
Marja R RaekallioSatu M Sankari

Abstract

To evaluate the adverse effects of carprofen in dogs after oral administration for 2 months. Prospective, randomized, blinded, placebo-controlled clinical trial. 22 dogs with osteoarthritis in the hip or elbow joint. 13 dogs received orally administered carprofen daily for 2 months, and 9 dogs received a placebo for 2 months. Dogs were weighed, and serum and urine samples were collected before initiation of treatment and 4 and 8 weeks after initiation of treatment. Serum concentrations of total protein, albumin, urea, and creatinine and serum activities of alkaline phosphatase (ALP) and alanine aminotransferase (ALT) were measured. Urinary ALP-to-creatinine, gamma-glutamyltransferase (GGT)-to-creatinine, and protein-to-creatinine ratios were calculated. Dogs were observed by owners for adverse effects. Serum protein and albumin concentrations were lower in treated dogs than in those that received placebo at 4 weeks, but not at 8 weeks. No changes were observed in serum urea or creatinine concentrations; ALP or ALT activity; or urinary ALP-to-creatinine, GGT-to-creatinine, or protein-to-creatinine ratios. Dogs' weights did not change. Severity of vomiting, diarrhea, and skin reactions did not differ between groups, but appetite ...Continue Reading

References

Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Mar 1, 1984·The New England Journal of Medicine·D M Clive, J S Stoff
Mar 1, 1984·The Medical Clinics of North America·M T StillmanJ L Blackshear
Mar 21, 1998·Toxicologic Pathology·F A Clemo
Oct 29, 1998·The Journal of Small Animal Practice·S F ForsythJ Godfrey
Feb 24, 1999·The Science of the Total Environment·M H MontfortsJ B Linders
Sep 28, 1999·Journal of Veterinary Internal Medicine·M E ReimerK Gimbert
Aug 10, 2000·Journal of the American Veterinary Medical Association·J C KoD F Mauragis
Jan 4, 2001·The Journal of Small Animal Practice·S F ForsythD U Pfeiffer
Mar 29, 2002·The Veterinary Record·T W Pennycott, K Venugopal

❮ Previous
Next ❯

Citations

Apr 3, 2007·American Journal of Veterinary Research·Marja R RaekallioS Marikki Peltoniemi
May 31, 2013·American Journal of Veterinary Research·Amy L LomasGregory F Grauer
Aug 27, 2013·Journal of the American Veterinary Medical Association·Rae G HutchinsShelly L Vaden
Oct 29, 2008·The Veterinary Clinics of North America. Small Animal Practice·Mark G Papich
Oct 29, 2008·The Veterinary Clinics of North America. Small Animal Practice·Spencer A JohnstonSteven C Budsberg
May 28, 2008·Research in Veterinary Science·P V M SteagallA Thomassian
May 3, 2007·Journal of Veterinary Pharmacology and Therapeutics·P V M SteagallS P L Luna
Dec 14, 2011·Veterinary Anaesthesia and Analgesia·Butch KuKanichOliver Knesl
Jun 21, 2013·Journal of Veterinary Internal Medicine·B P Monteiro-SteagallB D X Lascelles
Oct 17, 2012·Journal of Veterinary Pharmacology and Therapeutics·K A Vander WerfB Kukanich
Apr 22, 2015·Journal of Veterinary Emergency and Critical Care·Amy M KoenigshofL Ari Jutkowitz
Feb 24, 2015·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Simona CanceddaMassimo Vignoli
Jul 20, 2016·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·Amy S KapatkinKei Hayashi
Dec 10, 2013·Acta Cirúrgica Brasileira·Marina BorgesAlessandra Melchert
Feb 24, 2009·Toxicologic Pathology·Zaher A Radi
Feb 27, 2016·Veterinary Clinical Pathology·Jessica A Hokamp, Mary B Nabity
Jun 7, 2011·The Veterinary Record·A AutefageC Pepin-Richard
Dec 4, 2021·Scientific Reports·Cristhian Rene Vargas EstradaAndrigo Barboza De Nardi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.