Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants

International Journal of Food Sciences and Nutrition
Sirichai AdisakwattanaTipayanate Ariyapitipan

Abstract

The present study was to investigate in vitro alpha-glucosidase, pancreatic alpha-amylase and protein glycation inhibitory activities of nine edible plants. The results indicated that total phenolics, flavonoids, and condensed tannins of nine edible plants showed marked variations, ranging from 12.2 to 80.1 mg gallic acid equivalent/g extract, 2.34 to 13.65 mg quercetin equivalent/g extract, and 97.2 to 460.1 mg catechin equivalent/g extract, respectively. Our findings showed that grape seed, Cat's whiskers and Sweetleaf extract were the most effective pancreatic alpha-amylase, intestinal maltase, and sucrase inhibitor with IC(50) values of 0.29 +/- 0.01 mg/ml, 0.97 +/- 0.10 mg/ml and 0.86 +/- 0.01 mg/ml, respectively. All extracts (1 mg/ml) markedly inhibited the glycation of bovine serum albumin in fructose-mediated non-enzyme glycation by 50-30% at week 1. It was found that Pennywort maintained the high percentage inhibition among those of the extracts during the 4 weeks of experiment. These edible plants may be used for controlling blood glucose level and prevention of the development of type 2 diabetes.

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Citations

Jul 16, 2013·BMC Complementary and Alternative Medicine·Nattha JariyapamornkoonSirichai Adisakwattana
Jul 19, 2011·Journal of Clinical Biochemistry and Nutrition·Sirichai AdisakwattanaNatthakarn Wongsasiripat
Apr 9, 2014·BMC Complementary and Alternative Medicine·Sirichai AdisakwattanaCharoonsri Chusak
Nov 29, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weerachat SompongSirichai Adisakwattana
Apr 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wannaporn SuwannaphetSirichai Adisakwattana
Mar 30, 2016·European Journal of Pharmacology·Salah A GhareibAbdulrahman M Alahdal
Jan 2, 2014·International Journal of Endocrinology·Hugo Mendieta ZerónMiriam V Flores-Merino
Apr 19, 2015·BMC Complementary and Alternative Medicine·Poramin ChayaratanasinSirichai Adisakwattana
Feb 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hossam M AbdallahZainy M Banjar
Oct 29, 2011·Phytotherapy Research : PTR·Kathleen TerpendElodie Linares
Jan 10, 2018·BMC Complementary and Alternative Medicine·Charoonsri ChusakSirichai Adisakwattana
Nov 2, 2015·BMC Complementary and Alternative Medicine·Weerachat Sompong, Sirichai Adisakwattana
Feb 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iva FernandesVictor de Freitas
Mar 3, 2021·BMC Complementary Medicine and Therapies·Poramin ChayaratanasinThavaree Thilavech

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