Evaluation of alternatives to antibiotics using an Escherichia coli K88+ model of piglet diarrhea: effects on gut microbial ecology

Journal of Animal Science
S K BhandariD O Krause

Abstract

Enterotoxigenic Escherichia coli is a major problem in the swine industry and results in scouring, increased mortality, and poor performance in the period immediately postweaning. The traditional way to control this problem is to include subtherapeutic antibiotics in the feed, but this is no longer acceptable to consumers; thus, alternatives to antibiotics are needed. One of the supplements that has been effective in reducing scouring in the absence of antibiotics is animal blood products produced from the rendering process. This is also becoming a problem because of concerns regarding the transfer of transmissible spongiform encephalopathies to humans from animals. In this research, we investigated the effects of spray-dried porcine plasma (SDPP), a Bacillus subtilis direct-fed microbial (DFM), a blend of organic acids, and sweeteners on E. coli-induced scouring. A total of 108 pigs of approximately 17 d of age were assigned to 6 treatments, with 3 pigs per pen, in 2 blocks, with each block having 3 replicates. The 2 blocks were initiated approximately 2 mo apart, because a sufficient number of pigs were not available that met our inclusion criteria in the first block. Diet 1 was a negative control containing no antibiotics (N...Continue Reading

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Citations

Sep 5, 2008·Applied Biochemistry and Biotechnology·Kyoung-Sik HanPaul J Moughan
Sep 13, 2011·The British Journal of Nutrition·Mònica MaijóAnna Pérez-Bosque
Sep 29, 2009·Applied and Environmental Microbiology·Ehsan KhafipourDenis O Krause
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Sep 3, 2020·Journal of Animal Science·Yijie HeYanhong Liu
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