Evaluation of aluminum phthalocyanine chloride and DNA interactions for the design of an advanced drug delivery system in photodynamic therapy

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Cristiano Ceron JaymeAntonio Claudio Tedesco

Abstract

The aim of this study was to evaluate the interaction of aluminum phthalocyanine chloride (AlClPc) with double-stranded DNA. Absorption and fluorescence spectra, resonance light scattering, and circular dichroism were evaluated in water and water/ethanol mixtures with different concentrations of DNA or AlClPc. AlClPc showed a high ability to bind to DNA in both water and 4/6 water/ethanol mixture (v/v), with a majority of monomeric and aggregated initial forms of AlClPc, respectively. In this interaction, AlClPc bound preferentially to the grooves of DNA. The monomeric/aggregate state of AlClPc in DNA was dependent on the AlClPc/DNA ratio. At low concentrations of AlClPc, the interaction of AlClPc with few DNA sites caused a curvature in the DNA structure that provided a favorable environment for the intercalation of AlClPc aggregates. Increase in AlClPc concentration induced interactions with a high number of binding sites on DNA, which prevented bending and therefore aggregation of AlClPc molecules throughout the double-stranded DNA. These results are relevant to the understanding of the behavior and interaction of AlClPc with double-stranded DNA in the design of novel drug delivery systems for clinical application in photody...Continue Reading

Citations

Jun 24, 2020·Drug Delivery and Translational Research·Cristiano Ceron JaymeAntonio Claudio Tedesco
Mar 17, 2020·Photodiagnosis and Photodynamic Therapy·Leonardo Lobo Ribeiro CavalcanteSilmara Aparecida Milori Corona
Mar 9, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Évelin L de OliveiraWilker Caetano
Jul 4, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Defu ZhiRyan F Donnelly
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Antonio Claudio TedescoLeonardo P Franchi
May 20, 2021·Journal of Biomedical Materials Research. Part a·Cristiano Ceron JaymeAntonio Claudio Tedesco

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