PMID: 2117219Jan 1, 1990Paper

Evaluation of alveolitis by studies of lung biopsies

Lung
P L Haslam

Abstract

Immunocytochemical studies of lung biopsies from patients with cryptogenic fibrosing alveolitis and those having fibrosing alveolitis associated with scleroderma show that numerous T-cells occur in the alveolar walls and septa of all patients with these diseases, implying that cell-mediated hypersensitivity reactions are involved in the pathogenesis. However, B-lymphocytes, mainly within lymphoid follicles, are also present and, in the CFA group, such patients, and those with less than 50% T-suppressor/cytotoxic cells in the diffuse T-cell infiltrates, may have a poorer prognosis. Interleukin-2 receptor expression indicates that T-cell activation is occurring within the lungs, and there is evidence that interstitial monocytes/macrophages and alveolar epithelial cells may play a more important role in antigen presentation than alveolar macrophages. These observations on the features of the inflammatory response in the interstitial tissues of patients with fibrosing alveolitis need to be incorporated into the existing hypothesis on pathogenetic mechanisms based mainly on lavage findings of alveolar macrophages and granulocytes.

References

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Citations

May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F Levi-Schaffer, V B Weg
Jul 27, 2005·Respiratory Research·Zoe DaniilSpyros A Papiris
Nov 17, 2006·Respiration; International Review of Thoracic Diseases·Edwin Roger ParraVera Luiza Capelozzi
May 1, 1992·Clinical and Experimental Immunology·C Prior, P L Haslam
Jun 24, 1999·Pediatric Pulmonology·R RonchettiA Villani
Dec 23, 2008·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Adriana Ignacio de PaduaJosé Antônio Baddini Martinez

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