Evaluation of amantadine in chronic hepatitis C: a meta-analysis

Journal of Hepatology
Pierre DeltenrePhilippe Mathurin

Abstract

The benefit of amantadine combination therapy, either with interferon (IFN) alone (double therapy) or with ribavirin and IFN (triple therapy) is unknown. We analyzed the effect of amantadine on the end-of-treatment virological response and the sustained response using meta-analysis of 31 randomized controlled trials. Overall analysis revealed a significant effect of amantadine. Triple therapy was the best regimen for improving the sustained response (mean difference: 8.4%, 95% CI: 2.4-13.8%, P=0.002). In subgroup analysis, amantadine did not have a significant effect upon naive patients or relapsers. In non-responders, combination therapy with amantadine was associated with a significant effect on the sustained response (mean difference: 8.3%, 95% CI: 1.9-14.6%, P=0.01). In sensitivity analysis, double therapy did not improve virological responses. Conversely, triple therapy tended to improve the end-of-treatment virological response and was associated with a significant effect upon the sustained response (mean difference: 12.7%, 95% CI: 3.8-21.6%, P=0.005). Combination therapy with amantadine is of no effect upon naive patients or relapsers. In non-responders, triple therapy with amantadine improved the sustained response. New...Continue Reading

References

Apr 27, 1991·BMJ : British Medical Journal·M A Zuckerman, J S Oxford
Feb 23, 1991·BMJ : British Medical Journal·K G Nicholson, M J Wiselka
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Feb 19, 1987·The New England Journal of Medicine·H S SacksT C Chalmers
Feb 1, 1972·The Journal of General Virology·C J PfauC M O'Connell
Jan 1, 1965·Archiv für die gesamte Virusforschung·J S Oxford, G C Schild
Jul 1, 1980·Antimicrobial Agents and Chemotherapy·W C KoffS B Halstead
Jul 4, 1998·Lancet·A M Di Bisceglie
May 16, 2000·The American Journal of Gastroenterology·M KhaliliR Perrillo
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S BrillantiL Bolondi
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S ZeuzemU Hopf
Oct 31, 2000·Scandinavian Journal of Infectious Diseases·H SenturkS Badur
Feb 13, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·B GrahovacD Grgicevic
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·C AndantJ C Soulé
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·V Di MartinoJ F Cadranel
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A MangiaA Andriulli
Jul 27, 2001·Journal of Medical Virology·F TorreA Picciotto
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H MiyakawaM E Gershwin
Oct 30, 2001·Journal of Hepatology·A Craxi, O Lo Lacono
Jan 5, 2002·Journal of Gastroenterology·M Yagura, H Harada
Jan 12, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P AndreoneM Bernardi
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Beat HelblingUNKNOWN Investigators of the Swiss Association for the Study of the Liver
Jun 19, 2002·Annals of Internal Medicine·Thierry PoynardPierre Opolon
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Apr 19, 2003·Journal of Clinical Gastroenterology·Zobair M YounossiBelinda Yen Liebermann
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas BergStefan Zeuzem

❮ Previous
Next ❯

Citations

Dec 5, 2009·Digestive Diseases and Sciences·Jorge Méndez-NavarroMargarita Dehesa-Violante
Oct 21, 2010·Virologica Sinica·Xin Liang, Zhi-Yuan Li
Aug 6, 2008·Gastroentérologie Clinique Et Biologique·J-P BronowickiC Trépo
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen D C Griffin
Jan 16, 2007·Clinical Microbiology Reviews·Anette WohnslandChristoph Sarrazin
Dec 3, 2014·Computational Biology and Chemistry·Leon BichmannWolfgang B Fischer
Feb 26, 2013·Chemical Reviews·Lukas WankaPeter R Schreiner
Nov 26, 2010·Trends in Molecular Medicine·Michael A Gelman, Jeffrey S Glenn
May 22, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Paola Piccolo
May 12, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Martin-Walter WelkerBernd Kronenberger
Dec 19, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hanneke van SoestGreet J Boland
Apr 8, 2009·Gastroentérologie Clinique Et Biologique·J-P BronowickiH Barraud
Feb 24, 2007·Journal of Hepatology·Christian GluudRonald L Koretz
Oct 11, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael von WagnerStefan Zeuzem
Feb 21, 2008·Alimentary Pharmacology & Therapeutics·E Cholongitas, G V Papatheodoridis
Oct 2, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen GriffinMark Harris
Apr 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hirokazu UyamaNorio Hayashi
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Toshana L FosterStephen Griffin
Apr 5, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Saba KhaliqSajida Hassan
Sep 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Toshana L FosterStephen Griffin
Mar 21, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Rudolf E Stauber, Vanessa Stadlbauer
Jan 24, 2006·Journal of Hepatology·Marianne MaynardUNKNOWN French Multicenter Group
Apr 15, 2014·Journal of Clinical Epidemiology·Karen A RobinsonPaul Glasziou
May 30, 2015·The Journal of General Virology·Claire Scott, Stephen Griffin
Jul 28, 2012·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jian ChenYong Lin
Oct 7, 2008·Biophysical Journal·Chee Foong ChewPhilip C Biggin
Nov 20, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Astrid MarotPierre Deltenre
May 6, 2014·The Cochrane Database of Systematic Reviews·Mieke H LamersChristian Gluud
Oct 13, 2006·The Journal of Biological Chemistry·Dean ClarkeDavid Rowlands
Aug 25, 2015·World Journal of Hepatology·Fatih Ermis, Elif Senocak Tasci
Sep 19, 2006·World Journal of Gastroenterology : WJG·Silvia FargionUNKNOWN Gruppo Epatologico Lombardo

❮ Previous
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