Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women's Hospital tumor staging for cutaneous squamous cell carcinoma

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Pritesh S KariaChrysalyne D Schmults

Abstract

To compare American Joint Committee on Cancer (AJCC), International Union Against Cancer (UICC), and Brigham and Women's Hospital (BWH) tumor (T) staging systems for cutaneous squamous cell carcinoma and validate BWH staging against prior data. Primary tumors diagnosed from 2000 to 2009 at BWH (n = 1,818) were analyzed. Poor outcomes (local recurrence [LR], nodal metastasis [NM], and disease-specific death [DSD]) were analyzed by T stage with regard to each staging system's distinctiveness (outcome differences between stages), homogeneity (outcome similarity within stages), and monotonicity (outcome worsening with increasing stage). AJCC and UICC T3 and T4 were indistinct with overlapping 95% CIs for 10-year cumulative incidences of poor outcomes, but all four BWH stages were distinct. AJCC and UICC high-stage tumors (T3/T4) were rare at 0.3% and 3% of the cohort, respectively. Most poor outcomes occurred in low stages (T1/T2; AJCC: 86% [95% CI, 77% to 91%]; UICC: 70% [61% to 79%]) resulting in heterogeneous outcomes in T1/T2. Conversely, in BWH staging, only 5% of tumors were high stage (T2b/T3), but they accounted for 60% (95% CI, 50% to 69%) of poor outcomes (70% of NMs and 83% of DSDs) indicating superior homogeneity and mo...Continue Reading

References

Mar 29, 2001·The New England Journal of Medicine·M Alam, D Ratner
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary L ClaymanScott M Lippman
Jun 22, 2006·Annals of Surgical Oncology·John T MullenJanice N Cormier
Jan 27, 2009·Journal of Surgical Oncology·Frederick L Greene, Leslie H Sobin
May 6, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Anokhi Jambusaria-PahlajaniChrysalyne Delling Schmults
Aug 29, 2009·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Constantinos MourouzisClive Pratt
Nov 6, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Amy S RossChrysalyne D Schmults
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 17, 2010·Archives of Dermatology·Howard W RogersBrett M Coldiron
Nov 17, 2010·Archives of Dermatology·Anokhi Jambusaria-PahlajaniChrysalyne D Schmults
May 18, 2012·Journal of Surgical Oncology·Nicholas D L S BroughamSwee T Tan
Jan 18, 2013·JAMA Dermatology·Anokhi Jambusaria-PahlajaniChrysalyne D Schmults
Feb 5, 2013·Journal of the American Academy of Dermatology·Pritesh S KariaChrysalyne D Schmults

❮ Previous
Next ❯

Citations

Mar 21, 2017·Journal of the American Academy of Dermatology·Miriam Gonzalez-GuerreroJorge Santos-Juanes
Feb 17, 2017·American Journal of Otolaryngology·Eamon J McLaughlinJason G Newman
Jan 13, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jessica L GonzalezBichchau M Nguyen
Nov 29, 2016·The British Journal of Dermatology·J DuranC D Schmults
Jun 28, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Babu SinghBichchau M Nguyen
Nov 7, 2017·Healthcare·Artur FahradyanAlex K Wong
May 31, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Mittal, O R Colegio
Jun 15, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·An-Wen ChanPaula A Rochon
Jul 26, 2018·The New England Journal of Medicine·Kishwer S Nehal, Christopher K Bichakjian
Aug 28, 2018·Plastic and Reconstructive Surgery·Bernardino M Mendez, James F Thornton
Jan 24, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Cameron TrodelloAshley Wysong
Sep 28, 2017·The British Journal of Dermatology·S E LowensteinUNKNOWN National Cancer Institute Keratinocyte Carcinoma Consortium
Jun 26, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U HillenC Ulrich
Feb 23, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Shera FeinsteinAshley Wysong
May 28, 2016·CA: a Cancer Journal for Clinicians·Mary K TrippJeffrey E Gershenwald
Apr 10, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jessica L GonzalezBichchau Michelle Nguyen
Jan 15, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Adam B BlechmanMary L Stevenson
Nov 20, 2016·Journal of Cutaneous Pathology·Javier CañuetoConcepción Román-Curto
May 15, 2018·Clinical and Experimental Dermatology·J CañuetoC Román-Curto
Apr 13, 2020·Journal of Cutaneous Pathology·Sam WuPaul B Googe
Oct 1, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Antonio Tejera-VaquerizoOnofre Sanmartín
Aug 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dawn QueenLiang Liu
Jun 6, 2016·Current Treatment Options in Oncology·Teresa FuS Tyler Hollmig
Jul 1, 2016·American Journal of Clinical Dermatology·Kyle A BurtonAmor Khachemoune

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Helmut BreuningerHans-Martin Häfner
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Scott M Dinehart, Steven Peterson
Archives of Otolaryngology--head & Neck Surgery
Chul Hee LeeYang-Gi Min
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
C M BalchVernon K Sondak
© 2021 Meta ULC. All rights reserved