PMID: 8588493Jan 1, 1994Paper

Evaluation of amniotic fluid elastolytic activity: can it be a method of fetal lung maturity assessment? A comparison with Gluck's L/S test

Acta geneticae medicae et gemellologiae
G BazowskaJ Dudkiewicz

Abstract

Amniotic fluid elastolytic activity was assessed in a group of 120 women who delivered preterm infants and in 35 women who delivered at term. Amniotic fluid elastolytic activity decreases as pregnancy progresses. The lecithin-to-sphingomyelin (L/S) ratio in women's amniotic fluid was determined by the method developed by Gluck and associates [6] and elastolytic activity by that developed by Mehdi and associates. A significant negative correlation was found between the amniotic fluid L/S ratio and amniotic fluid elastolytic activity (r = -0.932; p < 0.001). The border value of elastolytic activity that indicates lung maturity (L/S ratio equal to or greater than 2) is 2.01 +/- 0.05 mmol/min ml. In the amniotic elastolytic activity test, it is the value that differentiates mature from immature lungs. The amniotic fluid elastolytic activity test is characterized by high sensitivity (91.43%) and specificity (91.67%), high positive prognostic value (76.19%) and low negative prognostic value (2.65%). The test parameters do not therefore differ greatly from those of the Gluck test. Moreover, the amniotic fluid elastolytic activity test is cheaper and takes less time to perform.

References

Sep 1, 1976·American Journal of Obstetrics and Gynecology·A C CruzW N Spellacy
Dec 1, 1991·Annals of Medicine·A H Jobe
Jan 30, 1990·Biochemical and Biophysical Research Communications·S MehdiP Bey
Mar 1, 1985·American Journal of Clinical Pathology·B E Statland, G Sher
Feb 1, 1986·Early Human Development·A A HislopR Desai
Feb 1, 1971·American Journal of Obstetrics and Gynecology·L GluckW N Spellacy
Apr 1, 1984·Environmental Health Perspectives·R B Rucker, M A Dubick
Jul 1, 1984·American Journal of Perinatology·G W Creasy, N V Simon

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Citations

May 8, 2020·Cells·Purvi C TrivediThomas Pulinilkunnil

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