PMID: 7547043Sep 1, 1995Paper

Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children

British Journal of Anaesthesia
R A LawsonN S Morton

Abstract

We have evaluated the efficacy and safety of a preparation of 4% amethocaine gel in alleviating the pain of venous cannulation in children. In an initial open study of 148 children, clinically acceptable anaesthesia was achieved in 92% of cases. The preparation was then compared with 5% EMLA cream in a single-blind study in 94 patients using an application time of 40 min. We found clinically acceptable conditions in 85% of patients receiving amethocaine gel compared with 66% in the EMLA group. There were no significant adverse effects noted in each group, although 37% of those children treated with amethocaine gel showed localized erythema at the application site. The results suggest that amethocaine gel has greater efficacy and a faster onset time than EMLA cream when used for this purpose in children.

Citations

Sep 29, 2005·Annals of Emergency Medicine·Anthony EidelmanDaniel B Carr
Jan 6, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C RömmenB C Lippold
Sep 29, 2001·Anaesthesia·M R Nott
Dec 22, 1999·Paediatric Anaesthesia·A ClarksonK O'Donnell
Feb 19, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·P M FriedmanR G Geronemus
Jun 6, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·William T Zempsky, Thomas M Parkinson
Oct 4, 2002·The New England Journal of Medicine·Charles B Berde, Navil F Sethna
May 23, 2002·Regional Anesthesia and Pain Medicine·María Dolores CárcelesNieves Vila
Nov 25, 2003·Regional Anesthesia and Pain Medicine·Isabelle MuratBarbara Tourniaire
May 23, 2006·Pediatric Emergency Care·Sara Skarbek-BorowskaP Allison Minugh
Mar 11, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Nedim SarifakiogluGürcan Aslan
Mar 2, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J Scott Henning, Bahar F Firoz
Mar 29, 2000·Archives of Disease in Childhood·J Arrowsmith, C Campbell
Mar 21, 2002·Emergency Medicine Journal : EMJ·S C MauriceT F Beattie
Jan 15, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·A Jain, N Rutter
Oct 21, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·A Jain, N Rutter
Oct 21, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·A Jain, N Rutter
Dec 23, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·A JainM Ratnayaka
Mar 9, 2012·Expert Opinion on Drug Safety·Suzanne BerkmanTina Alster
Jul 2, 2005·Expert Opinion on Investigational Drugs·G Cevc
Feb 11, 2016·Lasers in Medical Science·Clare Josephine TollanIain R Mackay
Sep 1, 1999·The Journal of Investigative Dermatology·C S Leopold, H I Maibach
Oct 26, 1999·The American Journal of Emergency Medicine·J A FeinC R Boardman
Jul 25, 2000·Journal of the American Academy of Dermatology·W Huang, A Vidimos
Mar 29, 2002·The Annals of Pharmacotherapy·Anna TaddioGideon Koren
Jan 16, 1999·Pediatric Clinics of North America·D Babich, J S Crollick
Jun 3, 2000·Pediatric Clinics of North America·W T Zempsky, N L Schechter
Apr 12, 2016·Korean journal of anesthesiology·Eun Kyung ChoiKi-Bum Park
Feb 6, 2017·The Cochrane Database of Systematic Reviews·Jann P FosterKaye Spence
Apr 24, 2004·Anesthesia and Analgesia·M I ArévaloJ Queralt
Oct 3, 2003·Pediatrics in Review·William T Zempsky, Neil L Schechter
Jun 17, 2006·Therapeutic Drug Monitoring·Anna TaddioVibhuti Shah
Aug 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Peter SzmukTiberiu Ezri
Sep 25, 2002·Paediatric Drugs·Joel B Gunter
Sep 24, 2005·Skin Pharmacology and Physiology·E EscribanoJ Queralt
Mar 15, 2014·The Cochrane Database of Systematic Reviews·Janice A LanderSharon S So

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.