Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice

Journal of Molecular Neuroscience : MN
Andrew HolmesJ Crawley

Abstract

Understanding the role of neuropeptides in mediating emotional behaviors is an important avenue for discovering novel drug targets for anxiety disorders. A role for galanin in mediating anxiety-related behavior is suggested by the pattern of distribution in the CNS and the coexistence of galanin with norepinephrine in the locus coeruleus. Studies in rats have shown that central administration of galanin modulates anxiety-related behaviors, and galanin release blocks the proanxiety effects of noradrenergic activation in prestressed rats. To further investigate the role of galanin in anxiety behaviors, we conducted a comprehensive behavioral phenotyping of galanin overexpressing transgenic mice (GAL-tg). GAL-tg mice were normal on measures of general health, neurological reflexes, home cage social behaviors, sensory functions, motor coordination, and exploratory locomotor activity. In three separate tests for anxiety-related behaviors, the elevated plus-maze, light <--> dark exploration, and open field center time, GAL-tg mice showed no anxiety-like phenotype. GAL-tg mice and wild-type littermate controls were equally responsive to the anxiolytic effects of chlordiazepoxide (10 mg/kg) in the light <--> dark exploration test, indi...Continue Reading

Citations

May 27, 2008·Cellular and Molecular Life Sciences : CMLS·J N Crawley
Dec 22, 2007·Neuroscience and Behavioral Physiology·V I LyudynoV M Klimenko
Nov 11, 2003·Trends in Pharmacological Sciences·Andrew HolmesGuy Griebel
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Sep 3, 2005·Nature Reviews. Drug Discovery·John F Cryan, Andrew Holmes
May 3, 2006·The Journal of Pharmacology and Experimental Therapeutics·Dustin W DuBoisBrian A McCool
Sep 9, 2008·The Journal of Experimental Biology·Susan C P RennHans A Hofmann
Jan 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takashi YoshitakeJan Kehr
May 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Susanne M BrunnerBarbara Kofler
Sep 28, 2010·Brain Research·Jill L SilvermanJacqueline N Crawley
Nov 27, 2015·Brain Research·David Weinshenker, Philip V Holmes
Dec 23, 2008·Behavioural Brain Research·Valentina SabinoEric P Zorrilla
Jul 20, 2007·Neuropeptides·S Johannes R RajaraoChad E Beyer
Jan 30, 2007·Pharmacology, Biochemistry, and Behavior·Kathleen R BaileyJacqueline N Crawley
Jun 20, 2003·The European Journal of Neuroscience·John F CryanHerman van Der Putten
Mar 16, 2004·The European Journal of Neuroscience·Craige C WrennJacqueline N Crawley
Oct 20, 2009·European Journal of Pharmacology·Sven Ove OgrenTomas Hökfelt
Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·Rose-Marie KarlssonJacqueline N Crawley
Dec 21, 2004·Biological Psychiatry·Victoria B Risbrough, Mark A Geyer
Nov 9, 2004·Journal of Chemical Neuroanatomy·Eugenia KuteevaTomas Hökfelt
Sep 4, 2007·Biochemical Pharmacology·Aviel Goodman
Apr 22, 2006·Pharmacology, Biochemistry, and Behavior·Craige C WrennJacqueline N Crawley

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