Evaluation of an Automated Proton Planning Solution

Curēus
Alexander R DelaneyMax Dahele

Abstract

Purpose Intensity-modulated proton therapy (IMPT) treatments are increasing, however, treatment planning remains complex and prone to variability. RapidPlanTMPT (Varian Medical Systems, Palo Alto, California, USA) is a pre-clinical, proton-specific, automated knowledge-based planning solution which could reduce variability and increase efficiency. It uses a library of previous IMPT treatment plans to generate a model which can predict organ-at-risk (OAR) dose for new patients, and guide IMPT optimization. This study details and evaluates RapidPlanTMPT. Methods IMPT treatment plans for 50 head-and-neck cancer patients populated the model-library. The model was then used to create knowledge-based plans (KBPs) for 10 evaluation-patients. Model quality and accuracy were evaluated using model-provided OAR regression plots and examining the difference between predicted and achieved KBP mean dose. KBP quality was assessed through comparison with respective manual IMPT plans on the basis of boost/elective planning target volume (PTVB/PTVE) homogeneity and OAR sparing. The time to create KBPs was recorded. Results Model quality was good, with an average R2 of 0.85 between dosimetric and geometric features. The model showed high predicti...Continue Reading

Software Mentioned

IMPT
NUPO
PCS
RapidPlan TM PT
RapidPlan

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