Evaluation of an electrolysis apparatus for inactivating antineoplastics in clinical wastewater

Chemosphere
Toyohide KobayashiTakashi Nakano

Abstract

We recently reported a system for inactivating antineoplastics in which sodium hypochlorite is supplied by the electrolysis of sodium chloride solution. In this study, we designed an electrolysis apparatus for inactivating the cytotoxicity of antineoplastics in clinical wastewater using the system. The apparatus consists of an electrolysis cell with platinum-iridium electrodes, a pool tank, a circulating system for wastewater, a safety system for explosive gas and overflow, and an exhaust duct. The free chlorine concentration increased linearly up to 6500 mg l(-1), and pH also increased to 9.0-10.0 within 2h, when 0.9% sodium chloride solution was electrolyzed. We examined its efficacy with model and clinical wastewaters. The reciprocal of dilution factor for disappearance of cytotoxicity using Molt-4 cells was compared before and after electrolysis. In the model wastewater, that was 9.10 x 10(4) before electrolysis, and 3.56 x 10(2) after 2h of electrolysis. In the clinical wastewater (n=26), that was 6.90 x 10(3)-1.02 x 10(6) before electrolysis, and 1.08 x 10(2)-1.45 x 10(4) after 2h of electrolysis. Poisonous and explosive gases released by the electrolysis were measured; however, they were found to be negligible in terms o...Continue Reading

References

Jan 11, 1992·Critical Reviews in Toxicology·R O BeauchampF W Kari
Jan 1, 1985·The Journal of Pharmacy and Pharmacology·M L Richardson, J M Bowron
Nov 1, 1968·American Industrial Hygiene Association Journal·H H Jones
Mar 1, 1997·Ecotoxicology and Environmental Safety·T Steger-HartmannA Hartmann
Dec 11, 1999·Environmental Health Perspectives·C G Daughton, T A Ternes
Jul 5, 2005·Chemosphere·Jun HiroseKouichi Sano

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Citations

Dec 14, 2011·Ecotoxicology and Environmental Safety·Toyohide KobayashiTakashi Nakano
Jan 23, 2013·Ecotoxicology and Environmental Safety·Takashi NakanoKouichi Sano
Dec 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aleksandra PieczyńskaEwa M Siedlecka

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