Evaluation of an extended set of 15 candidate STR loci for paternity and kinship analysis in an Austrian population sample.

International Journal of Legal Medicine
P GrubwieserW Parson

Abstract

We investigated 15 polymorphic short tandem repeat (STR) loci (D1S1656, D7S1517, D8S306, D8S639, D9S304, D10S2325, D11S488, D12S391, D14S608, D16S3253, D17S976, D18S1270, D19S253, D20S161, and D21S1437) which are not included in the standard sets of forensic loci. The markers were selected according to the complexity of the polymorphic region: Of the 15 investigated loci, 7 loci showed a simple repeat structure (D9S304, D10S2325, D14S608, D16S3253, D18S1270, D19S253, and D21S1437), 3 loci (D7S1517, D12S391, and D20S161) consisted of compound repeat units, and 5 loci (D1S1656, D8S306, D8S639, D11S488, and D17S976) showed a more complex polymorphic region partly including different repeat blocks and incomplete repeat units, which resulted in a relatively high proportion of intermediate alleles. A population study on a sample of 270 unrelated persons from Austria was carried out. We did not observe significant deviations from Hardy-Weinberg expectations. The combined probability of exclusion for the 15 loci was 0.99999998. In combination with the conventional set of STR markers included in commercially available kits (no linkage was observed between these 15 loci and the Powerplex 16 System loci), these markers are approved as hig...Continue Reading

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Citations

Jul 19, 2006·International Journal of Legal Medicine·Mikiko Soejima, Yoshiro Koda
Nov 10, 2006·International Journal of Legal Medicine·Sabine Lutz-BonengelUlrike Schmidt
Aug 21, 2009·International Journal of Legal Medicine·Isao YuasaJürgen Henke
Jan 21, 2010·International Journal of Legal Medicine·De-Jian LuHu Zhao
Sep 3, 2010·International Journal of Legal Medicine·Hsiao-Lin HwaTsang-Ming Ko
Oct 19, 2011·International Journal of Legal Medicine·Dejian LuHu Zhao
Mar 21, 2012·International Journal of Legal Medicine·Hsiao-Lin HwaTsang-Ming Ko
Oct 16, 2012·International Journal of Legal Medicine·Peng-Yu ChenYi-Ping Hou
Dec 17, 2008·Forensic Science International. Genetics·Dorit BeckerWerner Brabetz
Feb 27, 2007·Forensic Science International : Synergy·H AsamuraH Fukushima
Sep 11, 2014·International Journal of Legal Medicine·Stefania TurrinaDomenico De Leo
Aug 2, 2012·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Thorsten SchwarkNicole von Wurmb-Schwark
May 9, 2009·Analytical Chemistry·T A BrettellJ R Almirall
Apr 2, 2014·Pediatrics·Seiko FumotoAkira Oka

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