Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Brett G ZaniRobert Rabiner

Abstract

Percutaneous intramedullary fixation may provide an ideal method for stabilization of bone fractures, while avoiding the need for large tissue dissections. Tibiae in 18 sheep were treated with an intramedullary photodynamic bone stabilization system (PBSS) that comprised a polyethylene terephthalate (Dacron) balloon filled with a monomer, cured with visible light in situ, and then harvested at 30, 90, or 180 days. In additional 40 sheep, a midshaft tibial osteotomy was performed and stabilized with external fixators or external fixators combined with the PBSS and evaluated at 8, 12, and 26 weeks. Healing and biocompatibility were evaluated by radiographic analysis, micro-computed tomography, and histopathology. In nonfractured sheep tibiae, PBSS implants conformably filled the medullary canal, while active cortical bone remodeling and apposition of new periosteal and/or endosteal bone was observed with no significant macroscopic or microscopic observations. Fractured sheep tibiae exhibited increased bone formation inside the osteotomy gap, with no significant difference when fixation was augmented by PBSS implants. Periosteal callus size gradually decreased over time and was similar in both treatment groups. No inhibition of en...Continue Reading

References

Sep 1, 1975·Acta Orthopaedica Scandinavica·J Lindwer, A Van Den Hooff
Jan 26, 1999·Clinical Orthopaedics and Related Research·E Y ChaoH Aro
May 8, 2000·The Journal of the American Academy of Orthopaedic Surgeons·R J Brumback, W W Virkus
May 17, 2000·The Journal of Bone and Joint Surgery. British Volume·R G McCormackE H Schemitsch
Nov 21, 2002·The Annals of Thoracic Surgery·Piergiorgio TozziLudwig K von Segesser
Nov 15, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mihra S TaljanovicTim B Hunter
Nov 16, 2004·The Orthopedic Clinics of North America·Klaus-Dieter KuehnUdo Gopp
Jun 29, 2007·International Orthopaedics·Bernd FüchtmeierLukas Prantl
Sep 21, 2007·Orthopaedic Nursing·Noreen C Miller, Aaron E Askew
Nov 14, 2007·The Journal of Bone and Joint Surgery. British Volume·H-C Pape, P Giannoudis
Apr 23, 2009·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Yoichi KoikeKatsumi Sato
Jun 10, 2009·International Orthopaedics·Kiran Singisetti, M Ambedkar
Aug 31, 2013·Biomedical Journal·Po-Liang LaiI-Ming Chu

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Citations

Jan 31, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Amanda L McSweeneyRobert Rabiner
May 2, 2019·Geriatric Orthopaedic Surgery & Rehabilitation·Stavros OikonomidisRolf Sobottke
Nov 9, 2019·Journal of Bone and Joint Infection·Guido W Van OijenEsther M M Van Lieshout
May 11, 2019·Der Unfallchirurg·Thomas GausepohlDietmar Pennig
May 18, 2019·Der Unfallchirurg·Thomas GausepohlDietmar Pennig
Jul 23, 2021·Journal of Surgical Oncology·Mitchell S FourmanSantiago Lozano-Calderon

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