Evaluation of an optimal luteal phase support protocol in IVF

Acta Obstetricia Et Gynecologica Scandinavica
M Ludwig, Klaus Diedrich

Abstract

Luteal phase support has been shown in the past to be an essential part of ovarian stimulation protocols, especially the long protocol. It could be shown that hCG is as effective as is progesterone for luteal phase support but hCG is accompanied by a higher rate of complications. Progesterone can be administered in several routes. The oral, intramuscular (i.m.) and vaginal routes have been chosen frequently in the past. The oral route is ineffective, since progesterone has a low oral bioavailability (<10%), and a high rate of metabolites, which may result in side effects such as somnolence etc. Intramuscular administration provides very high serum levels of progesterone and this route is effective with regard to pregnancy rates. Injection of progesterone, however, is painful and cannot be done by the patient herself. The vaginal route is also effective, progesterone can be administered by the patient herself and progesterone is delivered directly to the uterus, where high levels are achieved (first uterine pass effect). Several studies could show, in the past, that the vaginal administration of progesterone is effective also with regard to the downregulation of uterine contractions. Crinone 8% Vaginal Gel is especially designed...Continue Reading

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Citations

Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M LudwigK Diedrich
Jan 30, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Kjell WånggrenHåkan Wramsby
Sep 18, 2001·Journal of Women's Health & Gender-based Medicine
Jul 26, 2013·Human Reproduction Update·Theodoros N SergentanisEleni Th Petridou
Mar 24, 2005·Gynecologic and Obstetric Investigation·Saleema NosarkaDebbie Grové
Dec 15, 2012·Reproductive Biology and Endocrinology : RB&E·Xi-Ru LiuHong-Bo Qi
Jul 14, 2006·American Journal of Reproductive Immunology : AJRI·Nathalie LédéeGérard Chaouat
Oct 11, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Baidya Nath ChakravartySanghamitra Ghosh
Oct 3, 2002·Hospital Medicine·Smruta Shanbhag, Siladitya Bhattacharya
Aug 20, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vittorio UnferGian Carlo Di Renzo
Jan 11, 2019·Human Fertility : Journal of the British Fertility Society·Elizabeth WeedinKarl Hansen
Mar 17, 2005·The Journal of Pharmacology and Experimental Therapeutics·Eve C FeinbergWilliam H Catherino
Jul 1, 2015·Current Opinion in Obstetrics & Gynecology·Israel Ortega, Juan Antonio García Velasco
Sep 13, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Berfu DemirUmit Goktolga
Mar 5, 2015·Journal of Obstetrics and Gynaecology of India·Laurel Stadtmauer, Kay Waud
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Sep 26, 2015·Journal of Obstetrics and Gynaecology of India·Gautam N Allahbadia
Oct 6, 2020·Frontiers in Endocrinology·Federica Di GuardoChristophe Blockeel
May 9, 2003·Reproductive Biomedicine Online·Alan S Penzias, Michael M Alper

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