Evaluation of an ultrasmall superparamagnetic iron oxide in MRI in a bone tumor model in rabbits

Journal of Magnetic Resonance Imaging : JMRI
C H BushW J Montgomery

Abstract

Ultrasmall superparamagnetic iron oxides (USPIOs) are a class of MRI contrast agents having moderately selective affinity for the reticuloendothelial cells of lymph nodes and bone marrow. This study evaluated a USPIO preparation, Combidex (Code 7227), in MRI of a rabbit bone tumor model. VX2 carcinoma implanted into the tibial marrow of nine subject rabbits was studied. After tumor growth, the subjects underwent MRI of their lesions both before and after intravenous administration of Code 7227. Code 7227 was judged subjectively to conspicuously reduce the signal intensity of normal marrow on some pulse sequences. A hypointense zone outlined the tumor margins on postcontrast imaging, which allowed improved visualization of the soft tissue component of the larger lesions. Accumulation of the contrast agent in a zone of inflammation outside the tumor margin was demonstrated on histologic sections of the lesions. Code 7227 deserves additional study as a potential contrast agent for MRI of bone tumors.

References

Jan 1, 1992·Gastrointestinal Radiology·P F HahnJ T Ferrucci
May 1, 1991·Radiology·E SenéterreJ Wittenberg

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Citations

Mar 17, 1999·Journal of Magnetic Resonance Imaging : JMRI·J W BulteJ A Frank
Oct 6, 2006·European Radiology·Heike E Daldrup-LinkThomas M Link
Jan 5, 2002·Magnetic Resonance Imaging·B J DardzinskiR Hirsch
May 15, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mukesh G HarisinghaniPeter F Hahn
Nov 10, 2012·American Heart Journal·Chiara MelloniL Kristin Newby
Jul 2, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Seung Hong Choi, Woo Kyung Moon
Mar 29, 2014·Journal of Tissue Engineering and Regenerative Medicine·Shihui ChenShekhar-Madhukar Kumta

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