Evaluation of androgens in the scalp hair and plasma of patients with male-pattern baldness before and after finasteride administration

The British Journal of Dermatology
H K RyuB C Chung

Abstract

Finasteride, a competitive inhibitor of the enzyme 5alpha-reductase II, is widely used as a medical treatment for patients with male-pattern baldness (MPB), which is affected by the distribution of androgenic steroids. It is also notable that the androgenic effect in MPB is different for each region of the head. To study the effect of the drug finasteride, we quantified androgenic steroids in the vertex and occipital scalp hair and in the plasma of patients with MPB. The patients with MPB, aged 23-52 years, were treated with finasteride 1 mg daily for 5 months. The hair and plasma samples were hydrolysed, extracted with n-pentane, and derivatized with MSTFA:NH4I:DTE (1000:4:5, v/w/w). We analysed the concentrations of dihydrotestosterone (DHT) and testosterone (T) in the hair and plasma using gas chromatography-mass spectrometry (GC-MS). In the hair, the ratio of DHT/T was decreased in the vertex scalp hair after the individual received finasteride (P < 0.005). However, we found no significant difference in the ratio of DHT/T in the occipital scalp hair before and after individuals received finasteride. Like the results in the vertex scalp hair, the ratio of DHT/T in the plasma was remarkably decreased after finasteride adminis...Continue Reading

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Citations

Mar 9, 2010·Cancer Epidemiology·Jonathan L WrightJanet L Stanford
Nov 16, 2012·The Journal of Investigative Dermatology·Man Ho ChoiBong Chul Chung
Jun 9, 2015·Hormone Molecular Biology and Clinical Investigation·Abdulmaged M TraishAhmad Haider
Jan 18, 2020·Metabolomics : Official Journal of the Metabolomic Society·Yu Ra LeeBong Chul Chung
Aug 25, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Amelia K Hausauer, Derek H Jones
Aug 30, 2019·The Journal of Dermatology·Yu Ra LeeBong Chul Chung
Feb 9, 2020·Fertility and Sterility·Abdulmaged M Traish
Jul 14, 2020·Skin Appendage Disorders· ArshdeepChakravarthi Rangachari Srinivas

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