Evaluation of Anterior Vertebral Interbody Fusion Using Osteogenic Mesenchymal Stem Cells Transplanted in Collagen Sponge

Clinical Spine Surgery : a Spine Publication
Wencheng YangXujun Chen

Abstract

The study used a rabbit model to achieve anterior vertebral interbody fusion using osteogenic mesenchymal stem cells (OMSCs) transplanted in collagen sponge. We investigated the effectiveness of graft material for anterior vertebral interbody fusion using a rabbit model by examining the OMSCs transplanted in collagen sponge. Anterior vertebral interbody fusion is commonly performed. Although autogenous bone graft remains the gold-standard fusion material, it requires a separate surgical procedure and is associated with significant short-term and long-term morbidity. Recently, mesenchymal stem cells from bone marrow have been studied in various fields, including posterolateral spinal fusion. Thus, we hypothesized that cultured OMSCs transplanted in porous collagen sponge could be used successfully even in anterior vertebral interbody fusion. Forty mature male White Zealand rabbits (weight, 3.5-4.5 kg) were randomly allocated to receive one of the following graft materials: porous collagen sponge plus cultured OMSCs (group I); porous collagen sponge alone (group II); autogenous bone graft (group III); and nothing (group IV). All animals underwent anterior vertebral interbody fusion at the L4/L5 level. The lumbar spine was harvest...Continue Reading

References

Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Alexander R VaccaroUNKNOWN North American Spine Society for Contemporary Concepts in Spine Care
Jul 17, 2004·Cell and Tissue Banking·Munish C Gupta, Sukanta Maitra
Mar 27, 2007·Journal of Biochemistry·Masahiko MaedaTadaaki Kirita
May 8, 2007·The Spine Journal : Official Journal of the North American Spine Society·Andrew A GumbsBauer Sumpio
Jun 15, 2007·American Journal of Surgery·Andrew A GumbsScott H Hanan
Jul 17, 2007·The Orthopedic Clinics of North America·Francis H ShenD Greg Anderson
Nov 21, 2009·Tissue Engineering. Part a·Jie YuanYi Lin Cao
Jan 30, 2010·Injury·Adam L ShimerAlexander R Vaccaro

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Citations

May 19, 2017·Tissue Engineering. Part B, Reviews·Rui M DuarteJorge Correia-Pinto
Mar 10, 2015·Neurosurgical Review·David OehmeGraham Jenkin
Aug 22, 2018·International Journal of Molecular Sciences·Takahiro MakinoTakashi Kaito
Apr 22, 2018·Current Osteoporosis Reports·Divya Rani BijukumarMathew T Mathew
Jun 16, 2021·Operative Neurosurgery·Joshua L GolubovskyMichael P Steinmetz

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Methods Mentioned

BETA
x-ray micro-CT
light microscopy

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