Evaluation of anthelmintic activity and in silico PASS assisted prediction of Cordia dichotoma (Forst.) root extract

Ancient Science of Life
Prasad G Jamkhande, Sonal R Barde

Abstract

Worm infection and associated complications are severe problems that afflict a large population worldwide. Failure of synthetic drugs in worm infections because of drug resistance has made alternative drug therapy desirable. Cordia dichotoma (Forst.) is an ethnomedicinal plant which is rich in several secondary metabolites. Traditionally, the plant has been claimed to have high medicinal properties including antimicrobial activity and cytotoxicity. The study begun with an aim to explore plant-based natural anthelmintic agents against Pheretima posthuma, an Indian earthworm. Methanol extract of the drug was obtained by successive soxhlet extraction. The extract was tested for different phytochemicals. Worms were exposed to 10 mg/ml, 25 mg/ml, 50 mg/ml, and 75 mg/ml concentrations of extract and standard drug, albendazole. A software-based tool, prediction of activity spectra for substances was used to estimate anthelmintic efficacy of plant metabolites. The phytochemical analysis revealed presence of alkaloids, tannins, glycosides, saponins, flavonoids, and phenols. The extract showed dose-dependent effects, affecting worm motility, viability, and mortality. It was also found that the biological activity spectrum of the plant ph...Continue Reading

Citations

Aug 31, 2016·Journal of Ethnopharmacology·Andréia C F SalgueiroGustavo O Puntel
Oct 31, 2017·Biomedicines·Mohammed ShoibeEhsan Suez
Jun 12, 2020·Frontiers in Pharmacology·Justice Afrifa CrentsilDorcas Osei-Safo
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samuel K KwofieMichael D Wilson

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