Evaluation of anti-invasion effect of resveratrol and related methoxy analogues on human hepatocarcinoma cells

Journal of Agricultural and Food Chemistry
Chia-Jui WengGow-Chin Yen

Abstract

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is also highly metastatic. Metastasis is considered to be the major cause of death in cancer patients. Resveratrol (3,5,4'-trihydroxystilbene) and related analogues have been reported as candidates to prevent cancer growth and invasion. The bioactivity of resveratrol-related analogues could be altered due to the presence and positioning of methoxy groups on the basic resveratrol chemical structure. This study investigated the effects and mechanism of action of resveratrol and its methoxy analogues on invasion of human hepatocarcinoma cells. The migratory and invasive abilities of phorbol 12-myristate 13-acetate (PMA)-treated HepG2 and PMA-untreated Hep3B cells were both reduced in a dose-dependent manner by treatment with resveratrol and 3,5,4'-trimethoxy-trans-stilbene (MR-3). Upon incubation of PMA-treated HepG2 cells with resveratrol (0-50 microM) or MR-3 (0-50 microM), the MMP-9 activity decreased but TIMP-1 protein increased in a dose-dependent manner. With resveratrol (0-50 microM) or MR-3 (0-1 microM) treatment on PMA-untreated Hep3B cells, both of the MMP-9 and MMP-2 activities decreased but TIMP-2 protein increased in a dose-dependent manner. Th...Continue Reading

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Citations

Apr 27, 2012·Journal of Agricultural and Food Chemistry·Cristina Andres-LacuevaMaría P Portillo
Nov 16, 2012·PloS One·Danielly Cristiny Ferraz da CostaJerson L Silva
Dec 12, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chiung-Man TsaiChia-Jui Weng
Aug 30, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gow-Chin YenChia-Jui Weng
May 4, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yen-Ling ChenChia-Jui Weng
Nov 6, 2015·Molecules and Cells·Jinhyun RyuSang Soo Kang
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Nov 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laetitia NivelleMichel Tarpin
Mar 29, 2011·The Journal of Organic Chemistry·Satoshi MochidaMasahiro Miura

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