Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn

Journal of Ethnopharmacology
Poonam DharmaniGautam Palit

Abstract

Ocimum sanctum (OS) is known to possess various therapeutic properties. We evaluated its anti-ulcerogenic activity in cold restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models in Sprague-Dawley rats, histamine-induced duodenal (HST) ulcer in guinea pigs, and ulcer-healing activity, in acetic acid-induced (AC) chronic ulcer model. We found that OS, decreased the incidence of ulcers and also enhanced the healing of ulcers. OS at a dose of 100 mg/kg was found to be effective in CRU (65.07%), ASP (63.49%), AL (53.87%), PL (62.06%), and HST (61.76%) induced ulcer models and significantly reduced free, total acidity and peptic activity by 72.58, 58.63, 57.6%, respectively, and increased mucin secretion by 34.61%. Additionally, OS completely healed the ulcers within 20 days of treatment in AC. We observed that anti-ulcer effect of OS may be due to its cytoprotective effect rather than antisecretory activity. Conclusively, OS was found to possess potent anti-ulcerogenic as well as ulcer-healing properties and could act as a potent therapeutic agent against peptic ulcer disease.

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Citations

May 10, 2005·Journal of Ethnopharmacology·Poonam DharmaniGautam Palit
Jan 1, 2010·Pharmacognosy Reviews·Priyabrata PattanayakSangram K Panda
Jul 28, 2012·Journal of Advanced Pharmaceutical Technology & Research·Phool ChandraAshoke Kumar Ghosh
Mar 13, 2014·Iranian Red Crescent Medical Journal·Mohamad Hosein FarzaeiGholam Reza Mohseni
Aug 1, 2013·Pharmacognosy Research·Samuel Adetunji OnasanwoTaiwo Olayemi Elufioye
Oct 14, 2014·Expert Opinion on Drug Metabolism & Toxicology·Sophia Yui Kau FongZhong Zuo
Sep 4, 2012·Journal of Ethnopharmacology·Oratai NeamsuvanKholeel Mosamae
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Dec 8, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·V LakshmiG Palit
Nov 28, 2006·Journal of Ethnopharmacology·M UmamaheswariT K Ravi
Sep 6, 2005·European Journal of Pharmacology·Dharmani PoonamPalit Gautam
Jul 5, 2005·Journal of Ethnopharmacology·Guillermo Schmeda-Hirschmann, Erdem Yesilada
Jul 1, 2013·Journal of Advanced Research·Daniele HermesLuzia V Modolo
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Sep 19, 2019·The Journal of Veterinary Medical Science·Chiu-Fang LeeFu-An Chen
May 18, 2021·Journal of Ethnopharmacology·Arun Kumar KhajuriaN S Bisht
Sep 26, 2021·Environmental Science and Pollution Research International·Mohsen FoadoddiniMehran Hosseini

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