PMID: 6353427Aug 1, 1983Paper

Evaluation of antiarrhythmic activity of prostaglandin F2 alpha in man

Prostaglandins, Leukotrienes, and Medicine
W SziegoleitW Förster


Since prostaglandin (PG) F2 alpha had been shown to act anti-arrhythmically in various animal models and also in preliminary investigations in man, further evaluation of this effect was made in 30 patients with cardiac extrasystoles and in 2 patients with tachycardias. PGF2 alpha was infused intravenously at individually adapted consecutive rates from 5 to 100 micrograms/min each for at least 5 min. In the incidence of extrasystoles a mean maximum decrease of 41% (P less than 0.001) was obtained. One patient showed repeated short interruptions of a ventricular tachycardia. A dose-dependent significant rise in blood pressure and no significant influences on heart rate, PQ interval and QRS interval of the ECG were found. It is concluded that PGF2 alpha has probably no practical importance for the therapy of cardiac arrhythmias.


Feb 1, 1978·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S S Ratnam, S M Karim
Nov 10, 1974·Prostaglandins·M C Koss, J Nakano
Jun 1, 1973·Prostaglandins·W FörsterP Mentz
Mar 1, 1971·British Journal of Pharmacology·H A LaveryG C Scroop
Jul 1, 1971·Cardiovascular Research·S M KarimK Hillier
Jan 1, 1969·European Journal of Pharmacology·S M KarimK Hillier
Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H J Mest, J Rausch
Jul 1, 1981·American Heart Journal·D N MohrJ E Markis

Related Concepts

Cardiac Arrhythmia
Diastolic Blood Pressure
Clinical Trials
Dose-Response Relationship, Drug
Electrocardiographic Recorders
Pulse Rate
Prostaglandins F

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