Evaluation of antibacterial activity of some traditionally used medicinal plants against human pathogenic bacteria

BioMed Research International
Bishnu P MarasiniKanti Shrestha

Abstract

The worldwide increase of multidrug resistance in both community- and health-care associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. We aimed to find the in vitro antibacterial activity of ethanolic extracts of 16 different traditionally used medicinal plants of Nepal against 13 clinical and 2 reference bacterial species using microbroth dilution method. The evaluated plants species were found to exert a range of in vitro growth inhibitory action against the tested bacterial species, and Cynodon dactylon was found to exhibit moderate inhibitory action against 13 bacterial species including methicillin-resistant Staphylococcus aureus, imipenem-resistant Pseudomonas aeruginosa, multidrug-resistant Salmonella typhi, and S. typhimurium. The minimum inhibitory concentration (MIC) values of tested ethanolic extracts were found from 31 to >25,000 μg/mL. Notably, ethanolic extracts of Cinnamomum camphora, Curculigo orchioides, and Curcuma longa exhibited the highest antibacterial activity against S. pyogenes with a MIC of 49, 49, and 195 μg/mL, respectively; whereas chloroform fraction of Cynodon dactylon exhibited best antibacterial activity against S. aureus w...Continue Reading

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Citations

Jun 19, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pai-Wei SuLi-Yeh Chuang
Apr 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hao JiangYongde Yue
Jun 10, 2017·Journal of Medical Microbiology·Janaina de Cássia Orlandi SardiPedro Luiz Rosalen
May 9, 2019·Journal of Tropical Medicine·Sarita ManandharRaj Kumar Dahal
May 23, 2019·Journal of Religion and Health·Krishnand LuximonMohamad Fawzi Mahomoodally
Nov 17, 2020·Frontiers in Pharmacology·Snehal KadamKarishma S Kaushik
Mar 26, 2021·Advances in Pharmacological and Pharmaceutical Sciences·Phillip MawireStanley Mukanganyama
Jul 25, 2021·International Journal of Molecular Sciences·Ismat MajeedLuigi Geo Marceanu
Aug 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Najwan JubairAyesha Fatima

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