PMID: 10576141Nov 27, 1999

Evaluation of antibody responses to pneumococcal vaccines with ELISA and opsonophagocytic assay

Journal of Korean Medical Science
K H Kim, J Y Seoh

Abstract

Antibodies to a capsular polysaccharide (PS) provide protection against Streptococcus pneumoniae which express the homologous capsular serotype, and pneumococcal vaccines are designed to induce antibodies in the capsular PS. Levels and opsonophagocytic capacity of antibodies to the capsular PS of S. pneumoniae serotype 19F were determined by sera from adults immunized with 23-valent S. pneumoniae capsular PS vaccines. Geometric means of IgG anti-19F antibody level and specific opsonic titer rise significantly after immunization. The level of anticapsular PS antibodies for S. pneumoniae 19F serotype is fairly well correlated (r2=O.63) with the opsonophagocytic activities of sera. However, 3.7% (1/27) of serum samples display strikingly less opsonophagocytic activity than expected on the basis of their antibody level. Thus, antibody level may be of general use in predicting vaccine-induced protection among adults for 19F serotype. However, the opsonic activity data suggest that antibody levels are not always indicative of functional antibody.

References

Aug 13, 2013·Epidemiology and Infection·J Y C ChanA Lee
Nov 24, 1999·Immunological Reviews·R M Ruprecht

Related Concepts

Mycoplasma pneumoniae
Vaccines
Serotyping
Phosphoglycerate Dehydrogenase Activity
Antibody Formation
Opsonin
Bacterial Vaccines
Immunization Domain
PHGDH wt Allele
Polyglobin

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.