Evaluation of Antidiarrheal Activity of Methanolic Extract of Maranta arundinacea Linn. Leaves

Advances in Pharmacological Sciences
Md Khalilur RahmanChandra Datta Sumi

Abstract

Diarrhea is one of the most common causes for thousands of deaths every year. Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Maranta arundinacea linn. (MEMA) leaves in rats and brine shrimp, respectively. Antidiarrheal effect was evaluated by using castor oil-induced diarrhea, enteropooling, and gastrointestinal motility tests at 200 mg/kg and 400 mg/kg body weight in rats where the cytotoxic activity was justified using brine shrimp lethality bioassay at different concentrations of MEMA. The extract showed considerable antidiarrheal effect by inhibiting 42.67% and 57.75% of diarrheal episode at the doses of 200 and 400 mg/kg, respectively. MEMA also significantly (p < 0.01) reduced the castor oil-induced intestinal volume (2.14 ± 0.16 to 1.61 ± 0.12 mL) in enteropooling test as well as intestinal transit (33.00 to 43.36%) in GI motility test, compared to their respective control. These observed effects are comparable to that of standard drug loperamide (5 mg/kg). On the other hand, in brine shrimp lethality test after 24 h, surviving brine shrimp larvae wer...Continue Reading

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Citations

Mar 14, 2017·Journal of Integrative Medicine·Olasupo Stephen AdeniyiVictoria Ojimaojo Edino
Dec 14, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Alian Désiré AfagnigniFrançois-Xavier Etoa
Apr 18, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Paul Aimé NoubissiRené Kamgang
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Zemene Demelash KifleSeyfe Asrade Atnafie

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