Evaluation of antifungal efficacy in an optimized animal model of Trichophyton mentagrophytes-dermatophytosis

Journal of Chemotherapy
M A GhannoumP K Mukherjee

Abstract

Dermatophytoses are known to cause considerable discomfort, cosmetic problems and financial loss that have been recognized as a significant health concern worldwide. Since currently available antifungal agents have limitations in their efficacy, new agents are being developed. This study was undertaken to optimize an in vivo model of experimental dermatophytosis for evaluation of the efficacy of antifungal compounds. Guinea pigs were infected with different inocula of T. mentagrophytes to establish dermatophytosis. The optimal conditions for dermatophytosis in guinea pigs were found to be an inoculum size of 1 x 10(7) fungal cells applied on abraded skin. After optimization, animals were treated with oral or topical formulations of terbinafine. The optimized guinea pig model was found to be highly reproducible, and useful in the primary screening and evaluation of the anti-dermatophytic efficacy of topical and oral formulations of antifungal agents.

References

Oct 1, 1991·Clinics in Dermatology·N H ShearC Marsolais
Apr 1, 1995·Clinical Microbiology Reviews·I Weitzman, R C Summerbell
Sep 10, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·A TostiM D Colombo
May 19, 2000·Medical Mycology·C J JessupM A Ghannoum
Jan 5, 2002·Expert Opinion on Investigational Drugs·M A Hossain, M A Ghannoum
Feb 9, 2002·International Journal of Hygiene and Environmental Health·A TreiberH C Schuppe

❮ Previous
Next ❯

Citations

Jun 10, 2008·Eukaryotic Cell·Theodore C WhiteMatthew R Henn
Jun 2, 2012·Indian Journal of Microbiology·Bindu SharmaSuresh Chandra Joshi
Apr 18, 2013·International Journal of Dermatology·Mahmoud A GhannoumBahram Memarzadeh
May 24, 2012·Journal of Biomedicine & Biotechnology·Tsuyoshi ShimamuraKazutoshi Shibuya
Jul 31, 2012·Microbes and Infection·James VenturiniMaria Sueli Parreira de Arruda
Oct 22, 2009·Natural Product Research·Berenice Aguilar-GuadarramaMaría Yolanda Rios
Dec 21, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Kai SunJiankang Yu
Jun 30, 2018·Experimental Dermatology·Émilie FawayYves Poumay
Oct 13, 2016·Mycopathologia·Ludivine CambierBernard Mignon
Jan 1, 2021·Journal of Photochemistry and Photobiology. B, Biology·Camila Barros GalinariPatrícia de Souza Bonfim-Mendonça
Feb 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Siu Wah Wong-DeyrupHong-Jie Zhang
Sep 28, 2021·Antimicrobial Agents and Chemotherapy·Esmat Mirbzadeh ArdakaniVahid Khalaj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.