PMID: 9421734Jan 9, 1998Paper

Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle

International Journal for Parasitology
S E EstuningsihT W Spithill

Abstract

Vaccine trials were conducted in Brahman cross cattle evaluating the efficacy of 4 native antigens purified from adult Fasciola gigantica flukes, and 1 recombinant F. gigantica antigen, as vaccines against tropical fasciolosis. The antigens tested were native glutathione S-transferase, cathepsin L, paramyosin, fatty acid binding protein (FABP), and a recombinant FABP expressed in E. coli, and were formulated in 1 or more of several adjuvants (Quil A, Squalene Montanide 80, MF59-100, Auspharm, NAGO, polylactoglycolide microspheres, Algammulin, DEAE, Freund's). Vaccination induced low, moderate or high antibody titres to the various antigens which were dependent on the adjuvant. Low but significant reductions in fluke burdens (31%, P < 0.026) and fluke wet weight (36%, P < 0.041) were only observed in cattle vaccinated with the native FABP in Freund's adjuvant. There was no correlation between total antibody titres to FABP and protection. The protection observed in cattle vaccinated with native FABP of F. gigantica supports the notion that this class of proteins is a useful target for protection of animals against Fasciola and extends the efficacy of FABPs to the tropical liver fluke. This is the first report of vaccination of ca...Continue Reading

References

Aug 1, 1992·Molecular and Biochemical Parasitology·F TrotteinA Capron
Jun 12, 1992·Science·B ZhengJ Rhodes
Nov 1, 1991·Tropical Animal Health and Production· SuhardonoI H Carmichael
Jun 1, 1991·Vaccine·P D CooperE J Steele
Jun 1, 1990·Australian Veterinary Journal·S E EstuningsihM R Knox
Mar 1, 1990·Molecular and Biochemical Parasitology·P M BrophyJ Barrett
Mar 1, 1989·The Journal of Clinical Investigation·T P FlaniganA A Mahmoud
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J PearceA Sher
Sep 1, 1988·Veterinary Parasitology·G V HillyerF Montealegre
Feb 1, 1987·International Journal for Parasitology·J P Fabiyi
Mar 1, 1986·Veterinary Parasitology·E T Haroun, G V Hillyer
Feb 1, 1995·Molecular and Biochemical Parasitology·L SalvatoreT W Spithill
Jul 1, 1995·Australian Veterinary Journal·D J Overend, F L Bowen
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·M TendlerA S Simpson
Mar 1, 1996·Veterinary Parasitology·D CleryG Mulcahy
Jan 1, 1996·Parasitology Research·J A RobertsE Estuningsih
Jan 1, 1997·Veterinary Parasitology·J A RobertsT W Spithill
Jan 1, 1996·Parasite Immunology·B L RamirezG R Olds
Dec 12, 1997·International Journal for Parasitology·T W SpithillP M Smooker
Dec 1, 1992·Parasitology Today·P M Brophy, D I Pritchard

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Citations

Jun 30, 2005·Parasitology Research·P Azhahia NambiMohini Saini
Jun 2, 2012·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·R L SharmaM B Thilagar
Dec 12, 1997·International Journal for Parasitology·T W SpithillP M Smooker
Feb 27, 1999·International Journal for Parasitology·W D Smith
Jun 6, 2000·Advanced Drug Delivery Reviews·T L Bowersock, S Martin
Oct 17, 2006·Parasitology Today·T W Spithill, J P Dalton
Mar 20, 2002·Veterinary Parasitology·H PaykariR Madani
May 1, 1999·Veterinary Parasitology·L K ShodaW C Brown
Dec 4, 2001·Biochimica Et Biophysica Acta·G AlviteA Esteves
Sep 11, 2004·The Journal of Parasitology·Ana M Espino, George V Hillyer
Apr 24, 2012·Veterinary Parasitology·F A Rojo-VázquezM Martínez-Valladares
Jan 21, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Adriana Esteves, Ricardo Ehrlich
Sep 10, 2014·International Journal for Parasitology·Hayley ToetTerry W Spithill

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